Robotic system for compounding medication

Patent metadata

Field	Value
Publication number	US-2016200462-A1
Application number	US-201414913442-A
Country	US
Kind code	A1
Filing date	Aug 24, 2014
Priority date	Aug 26, 2013
Publication date	Jul 14, 2016
Grant date	—

Abstract

The invention is a system designed to assist a hospital pharmacy in the compounding of medications comprising hazardous drugs. The system comprising: a safety cabinet, at least two robotic arm assemblies configured to simultaneously move vials and syringes within the safety cabinet, a plurality of cameras each installed at a specific location in the safety cabinet or on the robotic arm assemblies, and a processor. Each of the cameras is dedicated to provide real time digital images of the stage of the preparation process carried out at its location. Dedicated software and algorithms in the system processor allow almost all steps in the compounding process to be carried out automatically by the robotic arm assemblies without intervention by the operator or a supervisor and the cameras and imaging process algorithms are adapted to provide real-time feedback control of all stages of the compounding process.

First claim

1 . A system designed to assist a hospital pharmacy in the compounding of medications comprising hazardous drugs, the system comprising:
a. a safety cabinet; b. at least two robotic arm assemblies; c. a plurality of operational stations adapted to perform specific tasks related to the compounding process; d. a plurality of cameras each installed at a specific location in the safety cabinet or on the robotic arm assemblies, each camera dedicated to provide real time digital images of the stage of the preparation process carried out at that location; e. a system processor comprising: image processing algorithms to analyze the images received from the cameras; custom made algorithms to plan the timing and motions of the robotic arm assemblies and other devices inside the safety cabinet; custom made algorithms to execute the numerous comparisons and checks that are carried out to minimize errors in preparing the medications; and custom made software that manages the whole process and manages the data flow and the system database; and f. communication channels between the components of the system; wherein:
i. the robotic arm assemblies are adapted to simultaneously move vials and syringes within the safety cabinet;
ii. the robotic arm assemblies are adapted to allow almost all steps in the compounding process to be carried out automatically under guidance of the software and algorithms in the system processor without intervention by the operator or a supervisor; and
iii. the cameras and imaging process algorithms are adapted to provide real-time feedback control of all stages of the compounding process.

2 . The system of claim 1 wherein the safety cabinet comprises:
a. a work area above a working surface, the work area divided by a partition into a forward section and a rear section; the work area comprising:
i. at least one IV bag base module located in front of the partition;
ii. at least one reconstitution module located behind the partition, each reconstitution module adapted to allow at least one vial to be connected to it and to inject a predetermined volume of liquid into the vial;
iii. at least one vial shaker module located behind the partition, each vial shaker module adapted to allow one or more vials containing reconstituted drugs to be connected to it and shaken for a predetermined period of time and predetermined shaking method;
iv. at least one vial flipper module located behind the partition, each vial flipper module adapted to allow at least one vial to be connected to it and to invert the vials;
v. a vial insertion area located behind the partition;
vi. a vial internal storage area located behind the partition; and
vii. one vial robotic arm assembly comprising a vial gripper adapted to allow the vial robotic arm assembly to pick up and to rotate a vial, the vial robotic arm assembly adapted to allow it move a vial to any location behind the partition above the work surface and to release the vial at a new location or to connect the vial to and disconnect the vial from the reconstitution module, vial shaker module, and vial flipper module;

b. a closed area below the working surface comprising;
i. a syringe magazine comprising a plurality of syringe mounts attached to a conveyor belt driven by a motor, the syringe mounts adapted to allow a syringe to be hung on them by an operator; and
ii. at least one syringe pump robotic arm assembly each syringe pump robotic arm assembly comprising a syringe gripper assembly and a syringe pump, adapted to pick up a syringe from the syringe magazine and to attach the syringe to a syringe pump, which is adapted to draw liquid into and to eject liquid from a barrel of the syringe; each syringe pump robotic arm assembly adapted to move a syringe to locations inside the closed area and to connect the syringe to and disconnect the syringe from vials, IV bags, and infusion pump cartridges; and to discard used syringes.

c. an operator's display screen.

3 . The system of claim 1 additionally comprising at least one of: a supervisor's station, a label printer, a backup memory device, and a programmable logic controller adapted to receive instructions from the system processor and to activate the robotic arm assemblies and other operational stations inside the safety cabinet.

4 . The system of claim 2 wherein after a syringe pump has pulled a dose of drug from a vial, at least one image of the syringe is taken to check that there is no air bubble in the syringe barrel and to verify the position of the syringe piston in order to check that the correct volume of drug was pulled, wherein the checks are carried out automatically by image processing algorithms.

5 . The system of claim 4 wherein, after it has been verified that the syringe pump has pulled the correct volume of drug and that there is no air bubble in the syringe barrel, the syringe pump robotic arm assembly moves the filled syringe to an IV bag base module and connects it to a final prescription container that is locked in the IV bag base and from which the drug is to be administered to the patient.

6 . The system of claim 5 wherein, if the final prescription container is the syringe, it is connected to a syringe plug or other syringe holder and disconnected from the syringe robotic arm assembly.

7 . The system of claim 5 wherein, if the final prescription container is an IV bag or an infusion pump cartridge the syringe pump is activated to push the contents of the syringe into the final prescription container and an image of the syringe is taken and analyzed to verify that the syringe is empty before disconnecting it from the final prescription container.

8 . The system of claim 2 wherein a system operator manually loads vials into the vial insertion area in a random fashion.

9 . The system of claim 8 wherein, after the vials have been randomly placed in the vial insertion area by the operator, a picture of the vial is taken and the position of each vial is determined by an image processing algorithm, to allow sending the vial robotic arm to pick the vials.

10 . The system of claim 8 wherein, after the vials have been randomly placed in the vial insertion area by the operator, each vial is picked up by the vial robotic arm assembly and weighed and imaged and identified by the information on its label by the image processing algorithms and moved to a specific location in the vial internal storage area by the vial internal storage area.

11 . The system of claim 9 wherein, when a vial that has been previously placed in the vial internal storage area is required to fill a prescription, the software in the system processor sends instructions comprising the specific location at which the vial was inserted into the vial internal storage area to the vial robotic arm assembly.

12 . The system of claim 1 comprising one vial robotic arm assembly and at least two syringe pump robotic arm assemblies wherein the components of the system and the interactions between them are adapted to allow two prescriptions to be compounded in parallel.

13 . The system of claim 1 comprising components adapted to supply ozone for sterilization of the entire interior of the safety cabinet or for sterilization of specific locations within the safety cabinet

14 . The system of claim 1 wherein the components of the system and the interactions between them are adapted to allow separately performing each of the following pairs of operations:
a. reconstituting the drug in a vial while simultaneously identifying other vials;
b. identifying syringes while simultaneously identifying vials;
c. reconstituting the drug in a vial while

Assignees

• Equashield Medical Ltd
• Equashiled Medical Ltd

Inventors

• Kriheli Marino
• Shem-Tov Eric
• Daskal Gonen

Classifications

• G08B21/18

  Status alarms (G08B21/02 takes precedence) · CPC title

• B65B3/003 Primary

  Filling medical containers such as ampoules, vials, syringes or the like · CPC title

• G06Q10/06316

  Sequencing of tasks or work · CPC title

• B65B55/027

  Packaging in aseptic chambers · CPC title

• G07F17/0092

  for assembling and dispensing of pharmaceutical articles (medical dispensers for private use, A61J7/00) · CPC title