Arranging interaction and back pressure chambers for microfluidization

Patent metadata

Field	Value
Publication number	US-2016199486-A1
Application number	US-201615076776-A
Country	US
Kind code	A1
Filing date	Mar 22, 2016
Priority date	Dec 3, 2009
Publication date	Jul 14, 2016
Grant date	—

Abstract

An improved method for the manufacture of an oil-in-water emulsion comprises using a microfluidisation device whose interaction chamber comprises a plurality of Z-type channels upstream of a back pressure chamber.

First claim

1 . A microfluidization apparatus comprising an interaction chamber comprising at least one intensifier pump, and a back pressure chamber, wherein the interaction chamber and the back pressure chamber both comprise a plurality of fixed geometry channels and wherein the back pressure chamber is located downstream of the interaction chamber.

2 . The apparatus of claim 1 , wherein the channels in the interaction chamber include a plurality of substantially right-angled corners.

3 . The apparatus of claim 2 , wherein the channels in the interaction chamber include two substantially right-angled corners.

4 . The apparatus of claim 1 , wherein the fixed geometry of the channels in the interaction chamber is Z-type geometry.

5 . The apparatus of claim 1 , wherein the interaction chamber provides a shear rate in excess of 1×10 6 s −1 .

6 . A method for the manufacture of an oil-in-water emulsion comprising the step of passing a first emulsion having a first average oil droplet size through a microfluidization apparatus according to claim 1 .

Assignees

• Novartis Ag

Inventors

• Rueckl Harald
• Scheffczik Hanno

Classifications

• A61K2039/55555

  Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers · CPC title

• A61K31/164

  of a carboxylic acid with an aminoalcohol, e.g. ceramides · CPC title

• A61K47/26

  Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin · CPC title

• A61K9/0019

  Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00) · CPC title

• A61P31/16

  for influenza or rhinoviruses · CPC title