4-(phenoxyalkyl)thio)-phenoxyacetic acids and analogs

Patent metadata

Field	Value
Publication number	US-2016199342-A1
Application number	US-201615074125-A
Country	US
Kind code	A1
Filing date	Mar 18, 2016
Priority date	Sep 19, 2003
Publication date	Jul 14, 2016
Grant date	—

Abstract

The invention features 4-((phenoxyalkyl)thio)-phenoxyacetic acids and analogs, compositions containing them, and methods of using them as PPAR delta modulators to treat or inhibit the progression of, for example, dyslipidemia.

First claim

1 - 56 . (canceled)

57 . A method for treating or inhibiting the progression of a PPAR-delta mediated condition, said method comprising administering to a patient in need of treatment a pharmaceutically effective amount of compound of Formula (II):

wherein
X is selected from a covalent bond, S, or O;
Y is S or O;
- - - W - - - represents a group selected from —CH═, —CH 2 —, —CH 2 —CH 2 —, —CH 2 —CH═ and —CH═CH—;
Z is selected from O, CH, and CH 2 , provided when Y is O, Z is O;
R 1 and R 2 are independently selected from H, C 1-3 alkyl, C 1-3 alkoxy, halo, and NR a R b wherein R a and R b are independently H or C 1-3 alkyl;
R 3 and R 4 are independently selected from H, halo, cyano, hydroxy, acetyl, C 1-5 alkyl, C 1-4 alkoxy, and NR c R d wherein R c and R d are independently H or C 1-3 alkyl, provided that R 3 and R 4 are not both H;
n is 1 or 2;

or a pharmaceutically acceptable salt thereof.

58 - 92 . (canceled)

93 . The method of claim 57 wherein the compound is selected from the group consisting of
acetic acid, {4-[(2R)-2-hydroxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-;
acetic acid, {4-[(2S)-2-hydroxy-3-(4-trifluoromethyl-phenoxy)-propylsulfanyl]-2-methyl-phenoxy}-; and
{4-[2-ethoxy-3-(4-trifluoromethyl-phenoxy)-propoxy]-2-methyl-phenoxy}-acetic acid.

94 - 95 . (canceled)

Assignees

• Janssen Pharmaceutica Nv

Inventors

• Kuo Gee-Hong
• Zhang Rui
• Wang Aihua
• Deangelis Alan R

Classifications

• A61P9/00

  Drugs for disorders of the cardiovascular system · CPC title

• A61P3/10

  for hyperglycaemia, e.g. antidiabetics · CPC title

• A61P9/10

  for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis · CPC title

• A61P7/00

  Drugs for disorders of the blood or the extracellular fluid · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title