Compositions and methods for stimulating hair growth

Patent metadata

Field	Value
Publication number	US-2016199277-A1
Application number	US-201514829273-A
Country	US
Kind code	A1
Filing date	Aug 18, 2015
Priority date	Nov 9, 2009
Publication date	Jul 14, 2016
Grant date	—

Abstract

Methods and compositions for stimulating the growth of hair are disclosed wherein said compositions include a cyclopentane heptanoic acid, 2-cycloalkyl or arylalkyl compound represented by the formula I

wherein the dashed bonds represent the presence or absence of a double bond which can be in the cis or trans configuration and A, B, Z, X, R 1 and R 2 are as defined in the specification and a penetration enhancer. Such compositions are used in stimulating hair growth of human or non-human animals.

First claim

1 .- 20 . (canceled)

21 . A composition for topical application to human skin, the composition comprising:
0.01% to 5% w/w bimatoprost in free form or a pharmaceutically acceptable salt thereof; and, a penetration enhancer comprising a combination of
a first penetration enhancer group comprising ethanol, propylene glycol, and diethylene glycol monoethyl ether, and
a second penetration enhancer group comprising an effective amount of at least two compounds selected from the group consisting of glycerol monooleate, oleic acid, and benzyl alcohol.

22 . The composition of claim 21 , wherein the second penetration enhancer group comprises glycerol monooleate, oleic acid, and benzyl alcohol.

23 . The composition of claim 21 , wherein the bimatoprost penetrates the human skin to a greater extent than a second composition that does not comprise the second penetration enhancer group.

23 . The composition of claim 23 , wherein the composition comprises 5% w/w bimatoprost.

24 . The composition of claim 23 , wherein the composition comprises 1% w/w bimatoprost.

25 . The composition of claim 23 , wherein the composition comprises 0.3% w/w bimatoprost.

26 . The composition of claim 23 , wherein the composition comprises 0.1% w/w bimatoprost.

27 . The composition of claim 21 , wherein the composition is in the form of one selected from the group consisting of solutions, gels, ointments, foams, films, liniments, creams, shampoos, lotions, pastes, jellies, sprays, and aerosols.

28 . The composition of claim 21 , wherein the composition is in the form of a gel.

29 . The composition of claim 21 , wherein the composition is in the form of a solution.

30 . The composition of claim 21 , wherein the composition is in the form of a ointment.

28 . A method of stimulating hair growth, the method comprising topically administering the composition of claim 21 to a region of skin of a patient in need thereof.

29 . The method of claim 28 , wherein the region of skin is a scalp of the patient.

30 . The method of claim 28 , wherein the region of skin is a face of the patient.

31 . The method of claim 28 , wherein the region of skin is under or near one or more eyebrows of the patient.

32 . The method of claim 28 , wherein the region of skin is under or near one or more eyelids of the patient.

33 . The method of claim 28 , wherein the composition is administered to the skin once daily.

34 . The method of claim 28 , wherein the composition is administered to the skin twice daily.

35 . The method of claim 28 , wherein the composition comprises about 0.03% w/w to about 5% w/w bimatoprost.

36 . The method of claim 35 , wherein the composition comprises 1% w/w bimatoprost.

37 . The method of claim 28 , wherein administration of the composition is effective for the treatment of at least one of the conditions selected from the group consisting of alopecia areata, telogen effluvium, anagen effluvium, cicatricial alopecia, scarring alopecia; hair shaft abnormalities, trichorrexis nodosa, loose anagen syndrome, trichotillomania, traction alopecia, infectious hair disorders, tiniea capitis, sebohorreic dermatitis, follicullitus of the scalp, and androgenetic alopecia.

38 . The method of claim 28 , wherein the method stimulates the conversion of vellus hair to terminal hair.

39 . The method of claim 28 , wherein the method increases the rate of growth of terminal hair.

Assignees

• Allergan Inc

Inventors

• Trogden John T
• Salameh Adnan K
• Pujara Chetan P

Classifications

• A61P17/14

  for baldness or alopecia · CPC title

• A61K8/361

  Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof · CPC title

• A61K8/37

  Esters of carboxylic acids · CPC title

• A61K8/342

  Alcohols having more than seven atoms in an unbroken chain · CPC title

• A61K8/375

  the alcohol moiety containing more than one hydroxy group · CPC title