Dental composition containing polyoxometalates, process of production and use thereof

Patent metadata

Field	Value
Publication number	US-2016199267-A1
Application number	US-201414917047-A
Country	US
Kind code	A1
Filing date	Sep 4, 2014
Priority date	Sep 9, 2013
Publication date	Jul 14, 2016
Grant date	—

Abstract

The invention relates to a curable composition for dental use comprising polyoxymetalates and/or derivatives thereof in an amount of at least about 5 wt.-% with respect to the weight of the composition.

First claim

1 . A curable dental composition for dental use comprising:
a resin matrix comprising hardenable components, the hardenable components comprising a hardenable component with at least one acidic moiety (A1), an initiator system suitable for curing the hardenable components, polyoxometalate(s) and/or derivatives thereof being present in an amount of at least about 5 wt.-% with respect to the weight of the composition.

2 . The composition of claim 1 , wherein the polyoxometalate(s) is selected from dissolved polyoxometalate cluster(s), polyoxometalate particle(s) and combination(s) thereof.

3 . The composition of claim 1 , wherein the polyoxometalate(s) comprises a dissolved polyoxometalate cluster, wherein the dissolved polyoxometalate cluster is charge-balanced by a counter-cation, and wherein either the counter-cation or the polyoxometalate anion comprises an organic moiety which can comprise an unsaturated group.

4 . The composition of claim 1 , wherein the polyoxometalate comprises a dissolved polyoxometalate cluster(s), and wherein the dissolved polyoxometalate cluster(s) comprises polyoxometalate anion(s) being characterized by the formula (X x M m M′ n O y ) q− , with
X being selected from Cu, Zn, Co, Fe, B, Ga, Rh, Al, Cr, Mn, Ni, Ti, Zr, Si, Ge P, As, Te, I,
x being from about 0 to about 30,
m being from about 3 to about 248 and
n being from about 0 to about m/2,
y being from about 10 to about 720,
with the proviso that (0≦x<m+n),
M or M′ being one or more transition metal,
O being oxygen,
q being from about 1 to about 20.

5 . The composition of claim 1 , further comprising the polyoxymetalate(s) as dissolved polyoxometalate cluster(s), the dissolved polyoxometalate cluster(s) being characterized by at least one or all of the following features:
molecular size: from about 0.5 to about 5 nm, molecular weight: from about 800 to about 10,000 g/mol.

6 . The composition of claim 1 , wherein the hardenable components further comprises a component without an acidic moiety (A2).

7 . The composition of claim 1 , wherein the hardenable component with at least one acidic moiety (A1) is characterized by the following formula:
A n -B—C m
with A being an ethylenically unsaturated group, B being a spacer group selected from (i) linear or branched C1 to C12 alkyl, optionally substituted with halogen atoms and/or hydroxyl groups (ii) C6 to C12 aryl, optionally substituted with other functional groups with halogen atoms and/or hydroxyl groups, or (iii) organic group having 4 to 20 carbon atoms bonded to one another by one or more ether, thioether, ester, thioester, thiocarbonyl, amide, urethane, carbonyl and/or sulfonyl linkages, C being an acidic moiety, m, n being independently selected from 1, 2, 3, 4, 5 or 6, wherein the acidic moiety comprises one or more carboxylic acid residues, phosphoric acid residues, phosphonic acid residues, sulphonic acid residues, or sulfinic acid residues.

8 . The composition of claim 6 , wherein the hardenable component without an acidic moiety (A2) is characterized by the following formula:
A n -B-A m with A being an ethylenically unsaturated group, B being selected from (i) linear or branched C1 to C12 alkyl, optionally substituted with halogen atoms, and/or hydroxyl groups (ii) C6 to C12 aryl, optionally substituted with halogen atoms, and/or hydroxyl groups, or (iii) organic group having 4 to 20 carbon atoms bonded to one another by one or more ether, thioether, ester, thioester, thiocarbonyl, amide, urethane, carbonyl and/or sulfonyl linkages, m, n being independently selected from 0, 1, 2, 3, 4, 5 or 6 with the proviso that n+m is greater 0.

9 . The composition of claim 1 , wherein the initiator system is capable of initiating polymerization via radiation, heat, electronic beam, or redox chemical reaction and combinations thereof.

10 . The composition of claim 1 , wherein the initiator system comprises components comprising an acyl phosphine moiety, bisacylphosphine oxide, or combinations thereof, but not camphorquinone.

11 . The composition of claim 1 containing the components in the following amounts:
Resin matrix: from about 40 to about 80 wt.-%,
Initiator System: from about 0.5 to about 5 wt.-%,
Polyoxometalate(s): from about 5 to about 25 wt.-%,
wt.-% with respect to the weight of the whole composition.

12 . The composition of claim 1 being characterized by at least one, two or all of the following parameters:
Radiopacity: at least about 80% compared to an aluminum specimen of 1 mm thickness determined according to ISO 4049,
Storage stable,
pH value: from about 0 to about 6,
Viscosity: from about 0.1 Pa*s to about 1,000 Pa*s measured at 23° C.

13 . The composition of claim 1 not comprising components selected from nano-sized zirconia, acid-reactive filler or halogenated solvents or combinations thereof in amount above about 5 wt.-% with respect to the weight of the composition.

14 . The composition of claim 1 for use as or for the production of a filling material, adhesive, sealant, primer, cavity liner, cement, artificial crowns, artificial teeth, veneer or denture.

15 . (canceled)

Assignees

• 3M Innovative Properties Co

Inventors

• Miller Adam D
• Frey Matthew H
• Dunbar Timothy D
• Loll Henry
• Thalacker Christoph

Classifications

• A61K6/891 Primary

  Compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61K6/887

  Compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61K6/30

  Compositions for temporarily or permanently fixing teeth or palates, e.g. primers for dental adhesives · CPC title

• A61K6/71 Primary

  Fillers · CPC title

• A61K6/087 Primary

  Human Necessities · mapped topic