Conjugates for imaging

Patent metadata

Field	Value
Publication number	US-2016193371-A1
Application number	US-201614989498-A
Country	US
Kind code	A1
Filing date	Jan 6, 2016
Priority date	Jan 7, 2015
Publication date	Jul 7, 2016
Grant date	—

Abstract

The invention described herein relates to conjugates and compositions for imaging, diagnosing, and/or monitoring diseases using radionuclide-based imaging. In particular, the invention described herein relates to conjugates and compositions for imaging, diagnosing, and/or monitoring diseases using positron emission tomography.

First claim

What is claimed is:

1 . A conjugate, or a pharmaceutically acceptable salt thereof, of the formula

5 . The conjugate of claim 1 of the formula

or a pharmaceutically acceptable salt thereof.

6 . The conjugate of claim 1 of the formula

or a pharmaceutically acceptable salt thereof.

7 . The conjugate of claim 1 of the formula

or a pharmaceutically acceptable salt thereof.

8 . The conjugate of claim 1 of the formula

or a pharmaceutically acceptable salt thereof.

9 . The conjugate of claim 1 of the formula

or a pharmaceutically acceptable salt thereof.

10 . The conjugate of claim 1 wherein the conjugate, or pharmaceutically acceptable salt thereof, is complexed with 89 Zr.

11 . A composition comprising a conjugate, or a pharmaceutically acceptable salt thereof, of claim 1 .

12 . A kit comprising a conjugate, or a pharmaceutically acceptable salt thereof, of claim 1 .

Assignees

• Endocyte Inc

Inventors

• Vlahov Iontcho R
• Leamon Christopher P
• Santhapuram Hari Krishna R

Classifications

• A61K51/088 Primary

  conjugates with carriers being peptides, polyamino acids or proteins (antibodies A61K51/10) · CPC title

• A61K51/0459 Primary

  having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine · CPC title

• A61K51/02

  characterised by the carrier {, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus} · CPC title