Antisense Oligonucleotides (ODN) Against SMAD7 and Uses Thereof in Medical Field

Patent metadata

Field	Value
Publication number	US-2016177306-A1
Application number	US-201615063077-A
Country	US
Kind code	A1
Filing date	Mar 7, 2016
Priority date	Apr 2, 2003
Publication date	Jun 23, 2016
Grant date	—

Abstract

The invention relates to antisense oligonucleotidic sequences (ODN) against Smad7 suitably modified, and their uses in medical field as therapeutic biological agents, in particular in the treatment of chronic inflammatory bowel disease, such as Crohn's disease and ulcerative colitis.

First claim

1 - 16 . (canceled)

17 . An antisense oligonucleotide against Smad7 consisting of SEQ ID NO: 5:
5′-GTTTGGTCCTGAACATGC-3′, wherein at least one internucleoside linkage is a phosphorothioate linkage.

18 . The antisense oligonucleotide of claim 17 wherein all internucleoside linkages are phosphorothioate linkages.

19 . The antisense oligonucleotide of claim 17 wherein 2′-deoxyribonucleotides are replaced by corresponding ribonucleotides.

20 . A pharmaceutical composition comprising the antisense oligonucleotide of claim 17 and one or more pharmaceutically acceptable adjuvants or excipients.

21 . A method of treating Crohn's disease, comprising administering to a patient in need thereof an effective amount of the antisense oligonucleotide of claim 17 .

22 . A method of treating ulcerative colitis, comprising administering to a patient in need thereof an effective amount of the antisense oligonucleotide of claim 17 .

23 . A method of treating inflammatory bowel disease, comprising administering to a patient in need thereof an effective amount of the antisense oligonucleotide of claim 17 .

Assignees

• Nogra Pharma Ltd

Inventors

• Monteleone Giovanni

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P1/00

  Drugs for disorders of the alimentary tract or the digestive system · CPC title

• A61P1/04

  for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants · CPC title

• C12N15/1136 Primary

  against growth factors, growth regulators, cytokines, lymphokines or hormones · CPC title