Gas permeable material

Patent metadata

Field	Value
Publication number	US-2016177247-A1
Application number	US-201514976372-A
Country	US
Kind code	A1
Filing date	Dec 21, 2015
Priority date	Dec 22, 2014
Publication date	Jun 23, 2016
Grant date	—

Abstract

The invention describes a gas permeable fluoropolymer and silicone material used in the construction of cell culture bags.

First claim

What is claimed is:

1 . An oxygen permeable film comprising:
a first elastomer layer; and a second fluid contact layer having a total organic carbon (TOC) in water of less than 1 mg/cm 2 .

2 . The film of claim 1 , wherein the second fluid contact layer is a fluoropolymer layer, and wherein the first elastomer layer and second fluoropolymer layer are adhered together.

3 . The film of claim 1 , wherein the first elastomer layer comprises natural polyisopene rubber (NR), synthetic polyisoprene rubber (IR), polybutadiene rubber (BR), chloropene rubber (CR), butyl rubber (IIR), halogenated butyl rubbers (CIIR, BIIR), styrene-butadiene rubber (SBR), nitrile rubber (NBR) and hydrogenated nitrile rubber (HNBR), ethylene propylene rubber (EPM), ethylene propylene diene rubber (EPDM), epichlorohydrin rubber (ECO), polyacrylic rubber (ACM, ABR), silicone rubber (SI, Q, VMQ), fluorosilicone rubber (FSR, FVMQ), fluoroelastomers (FKM, FEPM), perfluoroelastomers (FFKM), polyether block amides (PEBA), chlorosulfonated polyethylene (CSM), ethylene-vinyl acetate (EVA), cyclic olefin copolymers, polyolefin elastomers, elastomeric PET, or mixture thereof.

4 . The film of claim 1 , wherein the first elastomer layer is polymethylpentene polymer (PMP).

5 . The film of claim 1 , wherein the first elastomer layer is silicone rubber.

6 . The film of claim 5 , wherein the silicone rubber is high consistency rubber (HCR), fluorosilicone rubber (FSR), liquid silicone rubber (LSR), room temperature vulcanized rubber (RTV), thermoplastic silicone rubber (TPE), platinum cured silicone rubber, or peroxide cured silicone rubber.

7 . The film of claim 2 , wherein the second fluoropolymer layer is fluorinated ethylene-propylene (FEP), polytetrafluoroethylene (PTFE), polyvinylidenefluoride (PVDF), tetrafluoroethylene-perfluoro(propyl vinyl ether) (PFA), polyvinylidene difluoride (PVF), polychlorotrifluoroethlylene (PCTFE), tetrafluoroethylene/hexafluoropropylene/ethylene copolymer (HTE), chlorotrifluoroethylene/vinylidenefluoride copolymer, chlorotrifluoroethylene/hexafluoropropylene, ethylene/chlorotrifluoroethylene copolymers (ECTFE), ethylene/trifluoroethylene copolymers, ethylene/tetrafluoroethylene copolymers (ETFE), tetrafluoroethylene/propylene copolymers (TFE/P), tetrafluoroethylene/hexafluoropropylene copolymers (FEP/HFP), hexafluoropropylene/tetrafluoroethylene/vinylidene copolymer (THV), or perfluoro(1-butenyl vinyl ether) homocyclopolymer having functionalized polymer-end groups

8 . An oxygen permeable container comprising:
an outer elastomer layer; and an inner fluid contact layer having a total organic carbon (TOC) in water of less than 1 mg/cm 2 .

9 . The container of claim 8 , wherein the fluid contact layer is a fluoropolymer layer, and wherein the inner fluoropolymer layer is adhered to the outer elastomer layer of the container.

10 . The container of claim 8 , wherein the outer elastomer layer comprises natural polyisopene rubber (NR), synthetic polyisoprene rubber (IR), polybutadiene rubber (BR), chloropene rubber (CR), butyl rubber (IIR), halogenated butyl rubbers (CIIR, BIIR), styrene-butadiene rubber (SBR), nitrile rubber (NBR) and hydrogenated nitrile rubber (HNBR), ethylene propylene rubber (EPM), ethylene propylene diene rubber (EPDM), epichlorohydrin rubber (ECO), polyacrylic rubber (ACM, ABR), silicone rubber (SI, Q, VMQ), fluorosilicone rubber (FSR, FVMQ), fluoroelastomers (FKM, FEPM), perfluoroelastomers (FFKM), polyether block amides (PEBA), chlorosulfonated polyethylene (CSM), ethylene-vinyl acetate (EVA), cyclic olefin copolymers, polyolefin elastomers, elastomeric PET, or mixtures thereof.

11 . The container of claim 8 , wherein the outer elastomer layer is polymethylpentene polymer (PMP).

12 . The container of claim 8 , wherein the outer elastomer layer is silicone rubber.

13 . The container of claim 12 , wherein the silicone rubber is high consistency rubber (HCR), fluorosilicone rubber (FSR), liquid silicone rubber (LSR), or room temperature vulcanized rubber (RTV), thermoplastic silicone rubber (TPE), platinum cured silicone rubber, or peroxide cured silicone rubber.

14 . The container of claim 9 , wherein the inner fluoropolymer layer is fluorinated ethylene-propylene (FEP), polytetrafluoroethylene (PTFE), polyvinylidenefluoride (PVDF), tetrafluoroethylene-perfluoro(propyl vinyl ether) (PFA), polyvinylidene difluoride (PVF), polychlorotrifluoroethlylene (PCTFE), tetrafluoroethylene/hexafluoropropylene/ethylene copolymer (HTE), chlorotrifluoroethylene/vinylidenefluoride copolymer, chlorotrifluoroethylene/hexafluoropropylene, ethylene/chlorotrifluoroethylene copolymers (ECTFE), ethylene/trifluoroethylene copolymers, ethylene/tetrafluoroethylene copolymers (ETFE), tetrafluoroethylene/propylene copolymers (TFE/P), tetrafluoroethylene/hexafluoropropylene copolymers (FEP/HFP), hexafluoropropylene/tetrafluoroethylene/vinylidene copolymer (THV), or perfluoro(1-butenyl vinyl ether) homocyclopolymer having functionalized polymer-end groups

15 . The container of claim 8 , wherein the container comprises a bag, flask, or tube.

16 . The container of claim 15 , wherein the bag, flask, or tube contains at least one sealable access port.

17 . A method to cultivate cells in an oxygen permeable container comprising the steps of:
a) adding media to the container; and b) adding cells, optionally with media, to the container, wherein the container comprises; an outer elastomer layer; and an inner fluid contact layer having a total organic carbon (TOC) in water of less than 1 mg/cm 2 .

18 . The method of claim 17 , where the inner fluid contact layer is a fluoropolymer layer, and wherein the inner fluoropolymer layer is adhered to the outer elastomer layer of the container.

19 . The method of claim 18 , wherein the inner fluoropolymer layer is fluorinated ethylene-propylene (FEP), polytetrafluoroethylene (PTFE), polyvinylidenefluoride (PVDF), tetrafluoroethylene-perfluoro(propyl vinyl ether) (PFA), polyvinylidene difluoride (PVF), polychlorotrifluoroethlylene (PCTFE), tetrafluoroethylene/hexafluoropropylene/ethylene copolymer (HTE), chlorotrifluoroethylene/vinylidenefluoride copolymer, chlorotrifluoroethylene/hexafluoropropylene, ethylene/chlorotrifluoroethylene copolymers (ECTFE), ethylene/trifluoroethylene copolymers, ethylene/tetrafluoroethylene copolymers (ETFE), tetrafluoroethylene/propylene copolymers (TFE/P), tetrafluoroethylene/hexafluoropropylene copolymers (FEP/HFP), hexafluoropropylene/tetrafluoroethylene/vinylidene copolymer (THV), or perfluoro(1-butenyl vinyl ether) homocyclopolymer having functionalized polymer-end groups

20 . The method of claim 17 , further comprising the step of incubating the container.

Assignees

• Saint Gobain Performance Plast

Inventors

• Clark Sarah Louise
• Lundgren Natasha Anna
• Tzivanis Michael John
• Zhu Aijun

Classifications

• C12M23/24 Primary

  Gas permeable parts · CPC title

• C12M23/14

  Bags · CPC title

• B32B2307/50

  having particular mechanical properties · CPC title

• B32B27/08

  of synthetic resin · CPC title

• B32B2307/7265

  Non-permeable · CPC title