Medical devices with an activated coating

Patent metadata

Field	Value
Publication number	US-2016175490-A1
Application number	US-201615054652-A
Country	US
Kind code	A1
Filing date	Feb 26, 2016
Priority date	Feb 21, 2009
Publication date	Jun 23, 2016
Grant date	—

Abstract

Implantable medical devices include a substrate having applied thereto a coating including a polymeric material possessing a core and at least one functional group known to have click reactivity.

First claim

1 . A method of producing a medical device comprising:
applying a coating composition including a natural polymer possessing a core and at least one functional group known to have click reactivity to a polymeric textile, whereby the coating composition imparts an activated surface to the textile via the functional group having click reactivity and the natural polymer is selected from the group consisting of chitosan, collagen, hyaluronic acid, polysaccharides and copolymers and combinations thereof.

2 - 6 . (canceled)

7 . The method according to claim 1 , wherein the functional group known to have click reactivity is selected from the group consisting in thiols, azides, alkynes and alkenes.

8 . The method according to claim 7 , wherein the functional group known to have click reactivity is a thiol.

9 . The method according to claim 7 , wherein the functional group known to have click reactivity is an azide.

10 . The method according to claim 7 , wherein the functional group known to have click reactivity is an alkyne.

11 . The method according to claim 7 , wherein the functional group known to have click reactivity is an alkene.

12 . The method according to claim 1 , wherein the natural polymer comprises chitosan.

13 . The method according to claim 1 , wherein the polymeric textile is a surgical mesh.

14 . The method according to claim 1 , wherein the polymeric textile is a sling.

15 . The method according to claim 1 , wherein applying the coating composition includes dipping, wiping, spraying, total immersion, or co-extrusion.

16 . The method according to claim 1 , wherein the coating composition comprises a solution or suspension.

17 . The method according to claim 1 , wherein the coating composition comprises a solvent.

18 . The method according to claim 1 , further comprising adding a bioactive agent possessing a functional group having click reactivity complementary to the functional group having click reactivity of the coating composition, wherein the bioactive agent covalently bonds to the coating composition.

19 . The method according to claim 18 , wherein the bioactive agent is selected from the group consisting of anti-adhesives, antimicrobials, analgesics, antipyretics, anesthetics, antiepileptics, antihistamines, anti-inflammatories, cardiovascular drugs, diagnostic agents, sympathomimetics, cholinomimetics, antimuscarinics, antispasmodics, muscle relaxants, adrenergic neuron blockers, antineoplastics, immunogenic agents, immunosuppressants, gastrointestinal drugs, diuretics, steroids, lipids, platelet activating drugs, dotting factors, chemotherapeutics and combinations thereof.

20 . The method according to claim 1 , wherein the polymeric textile comprises a non-absorbable polymer.

21 . The method according to claim 1 , wherein the polymeric textile comprises an absorbable polymer.

22 . The method according to claim 1 , wherein the polymeric textile comprises a knit.

23 . The method according to claim 1 , further comprising knitting a polymeric textile prior to applying the coating composition.

Assignees

• Sofradim Production
• Covidien Lp

Inventors

• Ladet Sébastien
• Hadba Ahmad Robert

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61L29/085

  Macromolecular materials · CPC title

• B05D1/00

  Processes for applying liquids or other fluent materials (B05D5/00, B05D7/00 take precedence) · CPC title

• A61L2420/02

  Methods for coating medical devices · CPC title

• A61L17/145

  Coating · CPC title