Electrospun dextran fibers and devices formed therefrom

Patent metadata

Field	Value
Publication number	US-2016175477-A9
Application number	US-201414445566-A
Country	US
Kind code	A9
Filing date	Jul 29, 2014
Priority date	Apr 11, 2008
Publication date	Jun 23, 2016
Grant date	—

Abstract

The invention generally relates to dextran fibers which are preferably electrospun and devices formed from such fibers. In particular, such devices may include substances of interest (such as therapeutic substances) associated with the electrospun fibers. Upon exposure to a liquid the electrospun fibers dissolve immediately and the substances of interest are released into the liquid. Exemplary devices include bandages formed from electrospun dextran fibers and associated agents that promote hemostasis, such as thrombin and fibrinogen.

First claim

1 . A hemostatic product comprising a plurality of hemostatic layers that each comprise:
a dextran support; and at least one hemostatic agent that is selected from the group consisting of thrombin and fibrinogen, wherein the hemostatic layers are arranged in a stacked configuration to form the hemostatic product.

2 . The hemostatic product of claim 1 , wherein the plurality of hemostatic layers comprise a first hemostatic layer and a second hemostatic layer, wherein the thrombin is associated with the first hemostatic layer and wherein the fibrinogen is associated with the second hemostatic layer.

3 . The hemostatic product of claim 1 , wherein the at least one hemostatic agent is placed on a surface of the dextran support and further comprising a top dextran support that covers the surface of the dextran support.

4 . The hemostatic product of claim 1 , wherein the hemostatic product comprises between about 5 and 10 of the hemostatic layers.

5 . The hemostatic product of claim 1 , wherein the dextran support comprises dextran fibers.

6 . The hemostatic product of claim 5 , wherein the dextran fibers are electrospun.

7 . The hemostatic product of claim 1 , wherein the dextran support has a moisture content of up to 5% by weight and wherein contact between the at least one hemostatic agent and the moisture causes the at least one hemostatic agent to be retained on the dextran support.

8 . The hemostatic product of claim 1 , wherein the hemostatic product further comprises a support material selected from the group consisting of gauze, electrospun dextran, polyglycolytic acid polymers, polylactic acid polymers, caprolactone polymers and charged nylon.

9 . The hemostatic product of claim 1 , wherein the dextran support is compressed.

10 . A method of preparing a hemostatic product comprising:
fabricating a plurality of hemostatic layers that each comprise:
a dextran support; and
at least one hemostatic agent associated with the dextran support, wherein the at least one hemostatic agent is selected from the group consisting of thrombin and fibrinogen; and
arranging the hemostatic layers in a stacked configuration.

11 . The method of claim 10 , wherein the plurality of hemostatic layers comprise a first hemostatic layer and a second hemostatic layer and wherein the method further comprises:
associating the thrombin with the first hemostatic layer; and associating the fibrinogen with the second hemostatic layer.

12 . The method of claim 10 , and further comprising:
placing the at least one hemostatic agent is placed on a surface of the dextran support; and covering the surface of the dextran support with a top dextran support.

13 . The method of claim 10 , wherein the hemostatic product comprises between about 5 and 10 of the hemostatic layers.

14 . The method of claim 10 , and further comprising placing one of the hemostatic layers on a support material that is selected from the group consisting of gauze, electrospun dextran, polyglycolytic acid polymers, polylactic acid polymers, caprolactone polymers and charged nylon.

15 . The method of claim 10 , and further comprising compressing the hemostatic layer to a height that is less than an initial height of the hemostatic layer.

16 . The method of claim 10 , wherein the dextran support comprises dextran fibers.

17 . The method of claim 16 , wherein the dextran fibers are electrospun.

Assignees

• Univ Virginia Commonwealth
• Jackson H M Found Military Med

Inventors

• Bowlin Gary
• Simpson David
• Bowman James
• Rothwell Stephen

Classifications

• A61L2300/252

  Polypeptides, proteins, e.g. glycoproteins, lipoproteins, cytokines · CPC title

• A61L15/28 Primary

  Polysaccharides or their derivatives {(A61L15/225 takes precedence)} · CPC title

• A61L2300/418

  Agents promoting blood coagulation, blood-clotting agents, embolising agents · CPC title

• A61L15/38

  containing enzymes · CPC title

• A61L15/44

  Medicaments · CPC title