Cyclohexyl beta-hydroxy alkyl amines and medical uses thereof
US-2024390298-A1 · Nov 28, 2024 · US
Antimetastatic compounds
US2016166553A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016166553-A1 |
| Application number | US-201615046827-A |
| Country | US |
| Kind code | A1 |
| Filing date | Feb 18, 2016 |
| Priority date | Aug 24, 2010 |
| Publication date | Jun 16, 2016 |
| Grant date | — |
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- Title
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Abstract
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Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of the MET receptor.
First claim
Opening claim text (preview).
1 - 133 . (canceled) 134 . A method of treating cancer comprising administering a compound or pharmaceutical composition comprising the compound of formula B-1a wherein A is —NHC(O); each of R 1 , R 2 , and R 3 if present is independently selected from halo, alkyl, alkoxy, optionally substituted aryl, hydroxyl; each of R 4 is nitro and R 5 if present is selected from halo, alkyl, alkoxy, C(O)alkyl, C(O)NH 2 , NH(CO)alkyl, NHalkyl, N(alkyl) 2 , nitro, C(O)aryl, optionally substituted heterocycle; and pharmaceutically acceptable salts thereof. 135 - 156 . (canceled) 157 . The method according to claim 134 , wherein R 1 is halo. 158 . The method according to claim 134 , wherein R 2 is alkyl. 159 . The method according to claim 157 , wherein R 2 is alkyl. 160 . The method according to claim 134 , wherein the compound of formula B-1a is selected from: 161 . The method according to claim 134 , wherein the compound is B-3. 162 . The method according to claim 134 , wherein the compound is B-4. 163 . The method according to claim 134 , wherein the compound is B-5. 164 . The method according to claim 134 , wherein the compound is B-6. 165 . The method according to claim 134 , wherein the compound is B-7. 166 . The method according to claim 134 , wherein the compound is B-8. 167 . The method according to claim 134 , wherein the compound is B-9. 168 . The method according to claim 134 , wherein the compound is B-10. 169 . The method according to claim 134 , wherein the compound is B-11. 170 . The method according to claim 134 , wherein the compound is B-12. 171 . The method according to claim 134 , wherein the compound is B-13.
Assignees
Inventors
Classifications
Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title
- A61K31/44Primary
Non condensed pyridines; Hydrogenated derivatives thereof · CPC title
Non-condensed quinolines and containing further heterocyclic rings · CPC title
specific for metastasis · CPC title
Sulfonamides (compounds containing a para-N-benzene-sulfonyl-N- group A61K31/63) · CPC title
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- What does patent US2016166553A1 cover?
- Screening methods for identifying compounds and compounds and pharmaceutical compositions for treating and preventing cancer are disclosed. The compounds affect signal transduction downstream of the MET receptor.
- Who is the assignee on this patent?
- Univ Brigham Young
- What technology area does this patent fall under?
- Primary CPC classification A61K31/44. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Thu Jun 16 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).