Improved powderous formulations of organic acids or esters having an aromatic ring system

Patent metadata

Field	Value
Publication number	US-2016166483-A1
Application number	US-201414907656-A
Country	US
Kind code	A1
Filing date	Jul 25, 2014
Priority date	Jul 26, 2013
Publication date	Jun 16, 2016
Grant date	—

Abstract

The present invention relates to improved powderous formulations comprising a high amount of at least one organic acids or esters having an aromatic ring system, as well as to the production of such formulations.

First claim

1 . A powderous formulation comprising
(i) 65-95 wt-%, based on the total weight of the powderous formulation, of at least one compound of formula (I)

wherein
X is —N— or —CH— and
R 1 is H or a C 1 -C 4 alkyl moiety, and
(ii) 5-35 wt-%, based on the total weight of the powderous formulation, of at least one auxiliary compound selected from the group consisting of aluminum ammonium sulphate, aluminum potassium sulfate, ammonium acetate, ammonium bisulphite, ammonium carbonate, ammonium chloride, ammonium dihydrogen phosphate, ammonium hydrogen carbonate, bentonite, montmorillonite, calcium aluminates, calcium carbonate, calcium silicate, synthetic calcium sulphate dihydrate, calcium sulfate, kaolinitic clays (such as Kaolin), diatomaceous earth, perlite, potassium bisulphite, potassium hydrogen carbonate, potassium sulphate, potassium carbonate, sepiolitic clays, silicic acid, synthetic sodium aluminosilicate, sodium aluminosulfate, sodium bisulphate, sodium carbonate, sodium chloride, sodium hydrogen carbonate, sodium sulphate, vermiculite, calcium carbonate, magnesium carbonate, calcareous marine algae, magnesium oxide, magnesium sulphate, dicalcium phosphate, tri-calcium phosphate, mono-dicalcium phosphate, defluorinated rock-phosphate, monocalcium phosphate, calcium-magnesium phosphate, mono-ammonium phosphate, magnesium phosphate, sodium-calcium-magnesium phosphate, mono-sodium phosphate, glycerol, propylene glycol (E 1520), glyceryl triacetate (E1518), sorbitol (E420), polydextrose, lactic acid and urea.

2 . A powderous formulation according to claim 1 , wherein the compound of formula (I) is a compound of formula (Ia) and/or (Ib)

3 . A powderous formulation according to claim 1 , wherein the auxiliary compounds have an average particle size (d 0.5) (in the powder formulation) of 10 μm-100 μm.

4 . A powderous formulation according to claim 1 , wherein the formulations have MIE values of 10-1000 mJ.

5 . A powderous formulation according to claim 1 , wherein the formulations have MIE values of more than 1000 mJ.

6 . A powderous formulation according to claim 1 , comprising 0-5 wt-%, based on the total weight of the formulation, of water.

7 . A powderous formulation according to claim 1 , wherein the formulations comprise
(ii) 10-30 wt-%, based on the total weight of the formulation, of at least one compound selected from the group consisting of ammonium dihydrogen phosphate, (purified) diatomaceous earth, potassium hydrogen carbonate, potassium sulphate, potassium carbonate, sodium chloride and sodium hydrogen carbonate.

8 . A powderous formulation according to claim 1 , wherein the formulations comprise
(iii) up to 40 wt-%, based on the total weight of the formulation, of at least one carrier material chosen from the group consisting of synthetically produced precipitated silica, formiate (such as calcium formiate), proteins, starches, lignosulfonates and gums.

9 . A powderous consisting of
(i) 65-95 wt-% (preferably 70-90 wt-%), based on the total weight of the powderous formulation, of

and
(ii) 5-35 wt-% (preferably 10-30 wt-%), based on the total weight of the powderous formulation, of at least one auxiliary compound selected from the group consisting of ammonium dihydrogen phosphate, (purified) diatomaceous earth, potassium hydrogen carbonate, potassium sulphate, potassium carbonate, sodium chloride, sodium sulphate and sodium hydrogen carbonate, and
0-5 wt-%, based on the total weight of the powderous formulation, of water.

10 . Use of at least one formulation according to claim 1 in food products, feed products and personal care products.

11 . Food products, feed products and personal care products comprising at least one formulation according to claim 1 .

Assignees

• Dsm Ip Assets Bv

Inventors

• Gadient Martin
• Aeschlimann Marie Agnes
• Isner Romeo

Classifications

• A61K9/14

  Particulate form, e.g. powders, {Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles (microspheres A61K9/16; microcapsules A61K9/50; nanocapsules, nanoparticles of the matrix type A61K9/51)} · CPC title

• A61K8/36

  Carboxylic acids; Salts or anhydrides thereof · CPC title

• A61Q19/00

  Preparations for care of the skin · CPC title

• A61K8/368

  with carboxyl groups directly bound to carbon atoms of aromatic rings · CPC title

• A61K47/02

  Inorganic compounds · CPC title