Porous and nonporous materials for tissue grafting and repair

Patent metadata

Field	Value
Publication number	US-2016166373-A9
Application number	US-201414216281-A
Country	US
Kind code	A9
Filing date	Mar 17, 2014
Priority date	Oct 25, 2005
Publication date	Jun 16, 2016
Grant date	—

Abstract

Implants having improved mechanical properties and/or degradation profiles, kits including such implants, and methods of producing and using the same.

First claim

What is claimed is:

1 . A device comprising:
a resorbable porous scaffold comprising a plurality of particles, the plurality of particles comprising at least one resorbable polymer, wherein at least a portion of the plurality of particles are fused together, the fused particles having a consolidated polymer structure.

2 . The device of claim 1 , wherein the at least one resorbable polymer is selected from the group consisting of poly(lactic acid), poly(glycolic acid), poly(lactide-co-glycolide), and combinations thereof.

3 . The device of claim 1 , wherein the porous scaffold includes at least two different resorption profiles, thereby providing a step-wise resorption.

4 . The device of claim 1 , wherein the porous scaffold comprises two or more polymers having at least two different resorption profiles including a first polymer and a second polymer.

5 . The device of claim 4 , wherein the first polymer has an inherent viscosity of about 0.5-1.5 and the second polymer has an inherent viscosity of about 4-7.

6 . The device of claim 4 , wherein the first polymer comprises 82:18 poly (L-lactide co-glycolide) and the second polymer comprises 85:15 poly (D, L lactide-co-glycolide).

7 . The device of claim 4 , wherein the first polymer comprises 70:30 poly (L/D,L lactide) and the second polymer comprises 82:18 poly(lactide-co-glycolide).

8 . The device of claim 1 , wherein the porous scaffold comprises a first polymer having a degradation time of about 6-9 months and a second polymer having a degradation time of about 2-3 months.

9 . The device of claim 1 , wherein the porous scaffold is a multi-phase composite.

10 . The device of claim 1 , wherein the porous scaffold is at least partially filled with a calcium-containing material selected from the group consisting of hydroxyapatite, tricalcium phosphate, calcium carbonate, calcium sulfate, and combinations thereof.

11 . The device of claim 1 , wherein the porous scaffold comprises macropores.

12 . The device of claim 1 , wherein the porous scaffold has substantially no microporosity.

13 . The device of claim 1 further comprising a coating on a surface of the resorbable porous scaffold.

14 . The device of claim 1 , wherein the porous scaffold is in the shape of a plurality of granules, a sheet, a rod, or a block.

15 . The device of claim 1 , wherein the device is selected from the group consisting of an interbody spacer, a fusion device, a bone graft, fusion cages, bone graft struts, structural augments, rods, screws, tacks, suture anchors, interference screws, a cartilage repair device, a tissue augmentation device, and a disc repair device.

16 . An implant comprising:
a resorbable porous scaffold comprising a plurality of particles, the plurality of particles comprising at least one resorbable polymer, wherein at least a portion of the plurality of particles are fused together, the fused particles having a consolidated polymer structure.

17 . A method of treating a patient comprising inserting into a patient the implant of claim 16 .

18 . The method of claim 17 further comprising applying at least one biologically active agent to the implant before inserting the implant into the patient.

19 . The method of claim 17 , wherein the at least one biologically active agent includes growth factors, cells, blood factors, antibiotic substances, demineralized bone matrix powder, and combinations thereof.

20 . A kit comprising:
the implant of claim 16 , and at least one device for placement, application of a biologically active agent, or shaping of the implant.

Assignees

• Globus Medical Inc

Inventors

• Borden Mark

Classifications

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L27/18 Primary

  obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds · CPC title

• A61L31/127

  containing fillers of phosphorus-containing inorganic materials · CPC title

• A61L31/146

  Porous materials, e.g. foams or sponges · CPC title

• A61F2/02 Primary

  Prostheses implantable into the body · CPC title