Cell image evaluation device, method, and program

Patent metadata

Field	Value
Publication number	US-2016163049-A1
Application number	US-201615046592-A
Country	US
Kind code	A1
Filing date	Feb 18, 2016
Priority date	Aug 22, 2013
Publication date	Jun 9, 2016
Grant date	—

Abstract

A cell image evaluation device includes an image acquisition unit that acquires a captured image of a cell, a cell evaluation unit that evaluates the cell image, and a maturity information acquisition unit that acquires information related to maturity of the cell. The cell evaluation unit determines a method for evaluating the cell image on the basis of the information related to the maturity.

First claim

What is claimed is:

1 . A cell image evaluation device comprising:
an image acquisition unit that acquires a captured image of a cell; a cell evaluation unit that evaluates the cell image; and a maturity information acquisition unit that acquires information related to maturity of the cell, wherein the cell evaluation unit determines a method for evaluating the cell image on the basis of the information related to the maturity.

2 . The cell image evaluation device according to claim 1 ,
wherein the cell evaluation unit evaluates the cell image using plural types of evaluation criteria.

3 . The cell image evaluation device according to claim 2 ,
wherein the cell evaluation unit gives different weights to the plurality of evaluation criteria and evaluates the cell image.

4 . The cell image evaluation device according to claim 2 ,
wherein the plural types of evaluation criteria include an evaluation criterion based on the uniformity of a distribution of the cells and an evaluation criterion based on a shape of a colony of the cells.

5 . The cell image evaluation device according to claim 2 ,
wherein the cell evaluation unit sets the weights such that a weight on an outward shape of the cell colony when the maturity is equal to or greater than a predetermined value is greater than a weight on the shape of the cell colony when the maturity is less than the predetermined value and evaluates the cell image.

6 . The cell image evaluation device according to claim 1 ,
wherein, when the maturity is equal to or greater than the predetermined value, the cell evaluation unit evaluates the cell image, using the uniformity of brightness of the cell image as the evaluation criteria.

7 . The cell image evaluation device according to claim 1 ,
wherein, when the maturity is equal to or greater than the predetermined value, the cell evaluation unit evaluates the cell image, using the uniformity of a thickness of the cell distributed in the cell image as the evaluation criteria.

8 . The cell image evaluation device according to claim 1 ,
wherein, when the maturity is equal to or greater than the predetermined value, the cell evaluation unit evaluates the cell image, using the approximation between a combination pattern of a plurality of circles and the cell colony as the evaluation criteria.

9 . The cell image evaluation device according to claim 1 ,
wherein the cell evaluation unit changes the cell image evaluation method on the basis of culture conditions of the cell.

10 . The cell image evaluation device according to claim 1 ,
wherein, when the culture conditions are that a cell different from the cell is used, the cell evaluation unit performs a process of separating an image of the different cell from the cell image.

11 . The cell image evaluation device according to claim 1 ,
wherein, in a case in which the maturity is in an initial stage of seeding, the cell evaluation unit performs a process of extracting the colony from the cell image when the culture condition is the seeding of the cell colony and does not perform the process of extracting the colony from the cell image when the culture condition is the seeding of a single cell.

12 . A cell image evaluation method comprising:
when a captured image of a cell is acquired and the acquired cell image is evaluated, acquiring information related to maturity of the cell; and determining a method for evaluating the cell image on the basis of the acquired information related to the maturity.

13 . A non transitory computer readable recording medium having a cell image evaluation program stored therein, that causes a computer to function as:
an image acquisition unit that acquires a captured image of a cell; a cell evaluation unit that evaluates the cell image; and a maturity information acquisition unit that acquires information related to maturity of the cell, wherein the cell evaluation unit determines a method for evaluating the cell image on the basis of the information related to the maturity.

Assignees

• Fujifilm Corp

Inventors

• Matsubara Kenta
• Matsumoto Tsuyoshi

Classifications

• G06V10/87

  using selection of the recognition techniques, e.g. of a classifier in a multiple classifier system · CPC title

• G06F18/285

  Selection of pattern recognition techniques, e.g. of classifiers in a multi-classifier system · CPC title

• G06T2207/30024

  Cell structures in vitro; Tissue sections in vitro · CPC title

• G02B21/14

  affording illumination for phase-contrast observation · CPC title

• G02B21/365

  Control or image processing arrangements for digital or video microscopes (G02B21/361, G02B21/362 take precedence) · CPC title