Synthetic peptide, and cosmetic composition or pharmaceutical composition and application thereof
US-2024352069-A1 · Oct 24, 2024 · US
Protease-resistant peptide ligands
US2016159859A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016159859-A1 |
| Application number | US-201414904715-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jul 15, 2014 |
| Priority date | Jul 15, 2013 |
| Publication date | Jun 9, 2016 |
| Grant date | — |
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- Title
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Abstract
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This invention relates generally to the discovery of novel protease-resistant peptide ligands and uses thereof. Specifically, the present invention provides a protease-resistant peptide with three to twenty amino acids capable of binding a biological and comprising one or more basic amino acid(s) and I or aromatic amino acids, wherein one or more of the amino acids is substituted with a non-naturally occurring amino acid analog.
First claim
Opening claim text (preview).
What is claimed is: 1 . A protease-resistant peptide comprising three to twenty amino acids capable of binding a biological and comprising one or more basic amino acid(s) or aromatic amino acids, wherein one or more of the amino acids is substituted with a non-naturally occurring amino acid analog. 2 . The protease-resistant peptide of claim 1 , wherein the non-natural amino acid analog is listed in Table 6. 3 . The protease-resistant peptide of claim 1 wherein the peptide is a hexapeptide. 4 . The protease-resistant peptide of claim 1 , wherein the protease-resistant peptide is a hexapeptide and has the sequence HWRGWV, HYFKFD and HFRRHL (SEQ ID NOS:1-3) prior to substitution with the non-naturally occurring amino acid analog(s). 5 . The protease-resistant peptide of claim 1 , wherein the peptide is resistant to digestion by endopeptidases. 6 . The protease-resistant peptide of claim 1 , wherein the peptide is resistant to digestion by exopeptidases. 7 . The protease-resistant peptide of claim 1 , wherein the endopeptidase is alpha-chymotrypsin. 8 . The protease-resistant peptide of claim 1 , wherein the endopeptidase is trypsin. 9 . A solid support coupled to the protease-resistant peptide of claim 1 . 10 . A method of purification of a biological which comprises contacting the solid support of claim 9 with the biological under suitable conditions such that the biological binds to the solid support; washing the solid support and bound biological; and eluting the biological from the solid support so as to purify the biological. 11 . The method of claim 10 , wherein the biological is an antibody. 12 . A diagnostic kit comprising the solid support of claim 9 .
Assignees
Inventors
Classifications
- C07K7/06Primary
having 5 to 11 amino acids · CPC title
having 12 to 20 amino acids (gastrins C07K14/595; somatostatins C07K14/655; melanotropins C07K14/68) · CPC title
Affinity chromatography or related techniques based upon selective absorption processes · CPC title
Purification, fragmentation · CPC title
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- What does patent US2016159859A1 cover?
- This invention relates generally to the discovery of novel protease-resistant peptide ligands and uses thereof. Specifically, the present invention provides a protease-resistant peptide with three to twenty amino acids capable of binding a biological and comprising one or more basic amino acid(s) and I or aromatic amino acids, wherein one or more of the amino acids is substituted with a non-nat…
- Who is the assignee on this patent?
- Univ North Carolina State
- What technology area does this patent fall under?
- Primary CPC classification C07K7/06. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu Jun 09 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).