Suturable hybrid superporous hydrogel keratoprosthesis for cornea

Patent metadata

Field	Value
Publication number	US-2016144069-A1
Application number	US-201615012110-A
Country	US
Kind code	A1
Filing date	Feb 1, 2016
Priority date	Jul 31, 2008
Publication date	May 26, 2016
Grant date	—

Abstract

The present invention features a superporous hydrogel scaffold for corneal regeneration or replacement and a method for producing the same. The superporous hydrogel is composed of a poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) copolymer mixed with collagen. The scaffold can be used as a suturable hybrid corneal implant or keratoprosthesis.

First claim

What is claimed is:

1 . A scaffold for corneal regeneration or replacement comprising a superporous hydrogel matrix comprising a poly(2-hydroxyethyl methacrylate) (PHEMA) and poly(methyl methacrylate) (PMMA) copolymer, and a cell adhesion agent in the pores of said superporous hydrogel matrix.

2 . The scaffold of claim 1 , wherein the cell adhesion agent is collagen.

3 . The scaffold of claim 1 , wherein the pores of the superporous hydrogel matrix have an average diameter of greater than 100 μm.

4 . The scaffold of claim 1 , wherein the pores of the superporous hydrogel matrix are connected to one another to form an open channel system.

5 . The scaffold of claim 1 , wherein the equilibrium swelling capacity of the superporous hydrogel matrix ranges from 50 to 500 g/g.

6 . The scaffold of claim 1 , wherein the superporous hydrogel matrix has an ultimate tensile strength of about 80 kPa or more.

7 . The scaffold of claim 1 , wherein the copolymer is formed by dissolving 2-hydroxyethyl methacrylate (HEMA) and methylmethyacrylate (MMA) monomers in a solvent and polymerizing the monomers at a temperature below 45° C. in the presence of a pore-forming agent.

8 . A suturable implant comprising the scaffold of claim 1 , wherein said implant forms the skirt of a core-skirt keratoprosthesis for implantation into the cornea.

9 . A method for producing the scaffold of claim 1 comprising
(a) dissolving 2-hydroxyethyl methacrylate (HEMA) and methylmethyacrylate (MMA) monomers in a solvent;
(b) polymerizing the monomers at a temperature below 45° C. in the presence of a pore-forming agent to form a superporous hydrogel matrix; and
(c) integrating a cell adhesion agent into the pores of the superporous hydrogel matrix.

10 . The method of claim 9 , wherein the cell adhesion agent is collagen.

Assignees

• Univ Illinois

Inventors

• Cho Michael
• Zellander Amelia

Classifications

• A61L27/52 Primary

  Hydrogels or hydrocolloids · CPC title

• A61L27/56

  Porous materials, {e.g. foams or sponges} · CPC title

• A61L2400/18

  Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment · CPC title

• A61L2430/16

  for reconstruction of eye parts, e.g. intraocular lens, cornea · CPC title

• A61L27/26 Primary

  Mixtures of macromolecular compounds · CPC title