Iron oxide magnetic particles
US-2024058449-A1 · Feb 22, 2024 · US
Nanoparticles for magnetic particle imaging applications
US2016136307A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016136307-A1 |
| Application number | US-201514941307-A |
| Country | US |
| Kind code | A1 |
| Filing date | Nov 13, 2015 |
| Priority date | Nov 14, 2014 |
| Publication date | May 19, 2016 |
| Grant date | — |
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Abstract
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One method of preparing a nanoparticle can include decomposing a compound at a high temperature, adding an acid to the solvent to form a reaction mixture, increasing the temperature of the reaction mixture to boiling point of the reaction mixture, and heating the reaction mixture at the boiling point for 60 to 120 minutes to produce the nanoparticle. The coated nanoparticle or the nanoparticle can be used in magnetic particles imaging.
First claim
Opening claim text (preview).
What is claimed is: 1 . A method of preparing a nanoparticle comprising: decomposing a compound at a temperature of 290° C.-390° C. in a solvent, adding an acid to the solvent to form a reaction mixture, increasing the temperature of the reaction mixture to boiling point of the reaction mixture, and heating the reaction mixture at the boiling point for 60 to 120 minutes to produce the nanoparticle. 2 . The method of claim 1 , wherein the acid includes an oleic acid. 3 . The method of claim 1 , wherein the acid includes a stearic acid. 4 . The method of claim 1 , wherein the acid includes a nonadecanoic acid. 5 . The method of claim 1 , wherein the solvent includes a 1-hexadecene, a 1-octadecene, a 1-eicosene, a 1-dococene, or a 1-tetracosane, or a mixture thereof. 6 . The method of claim 1 , wherein the compound includes an iron oleate. 7 . The method of claim 1 , wherein the nanoparticle includes magnetite. 8 . The method of claim 1 , wherein the nanoparticle has a size of between 15 and 35 nm. 9 . A method for magnetic particle imaging comprising: introducing a nanoparticle that includes magnetite and has a size of between 15 and 35 nm into a subject; and creating a magnetic particle imaging signal of the subject. 10 . An imaging composition comprising: a nanoparticle including magnetite and has a size of between 15 and 35 nm. 11 . The imaging composition of claim 10 , wherein the nanoparticle includes a silica shell. 12 . The imaging composition of claim 10 , wherein the nanoparticle includes a polyalkylene glycol coating.
Assignees
Inventors
Classifications
Ferroso-ferric oxide [Fe3O4] · CPC title
the organic macromolecular compound being polyethyleneglycol [PEG] · CPC title
obtained by TEM, STEM, STM or AFM · CPC title
- A61K49/1818Primary
particles, e.g. uncoated or non-functionalised microparticles or nanoparticles · CPC title
having a (super)(para)magnetic core coated or functionalised with an inorganic material or being composed of an inorganic material entrapping the MRI-active nucleus, e.g. silica core doped with a MRI-active nucleus · CPC title
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- What does patent US2016136307A1 cover?
- One method of preparing a nanoparticle can include decomposing a compound at a high temperature, adding an acid to the solvent to form a reaction mixture, increasing the temperature of the reaction mixture to boiling point of the reaction mixture, and heating the reaction mixture at the boiling point for 60 to 120 minutes to produce the nanoparticle. The coated nanoparticle or the nanoparticle …
- Who is the assignee on this patent?
- Massachusetts Inst Technology
- What technology area does this patent fall under?
- Primary CPC classification A61K49/1818. Mapped technology areas include Human Necessities.
- When was this patent published?
- Publication date Thu May 19 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).