Methods and compositions for synthesis of two-photon cleavable phosphoramidite molecules for oligonucleotide conjugation
US-11938187-B2 · Mar 26, 2024 · US
US2016136286A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016136286-A1 |
| Application number | US-201615005127-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jan 25, 2016 |
| Priority date | Jun 6, 2008 |
| Publication date | May 19, 2016 |
| Grant date | — |
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There is provided a non-water soluble drug delivery composition comprising a conjugate and a polymer matrix wherein exposure of the composition to electromagnetic radiation at a suitable pre-determined wavelength and intensity induces release of the active ingredient from the composition. The conjugate is attached to the polymer matrix through non-covalent interactions. There is also provided a drug delivery apparatus formed from the drug delivery composition.
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1 . A non-water soluble drug delivery composition comprising; a conjugate and a polymer matrix, said conjugate comprising an active ingredient bonded to a protecting group; wherein exposure of the composition to electromagnetic radiation at a suitable pre-determined wavelength and intensity induces release of the active ingredient from the composition; wherein the polymer matrix is formed from one or more copolymer compounds; and wherein the, or one of the, copolymer compounds comprises t…
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