Methods and compositions for enhancing cognitive performance

Patent metadata

Field	Value
Publication number	US-2016136192-A1
Application number	US-201414897462-A
Country	US
Kind code	A1
Filing date	Jun 10, 2014
Priority date	Jun 10, 2013
Publication date	May 19, 2016
Grant date	—

Abstract

Compositions including an effective amount of each of phosphatidyl serine, choline, and oleic acid, and methods for improving cognitive performance that include administering such compositions to a subject, are described herein. The compositions can be nutritional compositions such as bars or liquids suitable for oral administration. The combination of phosphatidyl serine, choline, and oleic acid provides synergistic or complimentary modes of action that improve the overall effect of these compounds.

First claim

1 . A method of improving cognitive performance, comprising orally administering a composition comprising an effective amount of each of phosphatidyl serine, choline, and oleic acid to a subject.

2 . The method of claim 1 , wherein the subject is a human.

3 . The method of claim 1 , wherein the composition is a nutritional composition.

4 . The method of claim 3 , wherein the nutritional composition contains 150-500 calories per serving and is in the form of a powder suitable for reconstitution to a liquid, a liquid or a bar.

5 . The method of claim 3 , wherein the nutritional composition further comprises at least one source of carbohydrate and at least one source of protein.

6 . (canceled)

7 . The method of claim 5 , wherein the carbohydrate comprises sucrose and the protein comprises casein.

8 . The method of claim 1 , wherein the amount of phosphatidyl serine ranges from 20 mg/day to 600 mg/day.

9 . The method of claim 1 , wherein the amount of choline ranges from 20 mg/day to 600 mg/day.

10 . (canceled)

11 . The method of claim 1 , wherein the amount of oleic acid ranges from 0.1 g/day to 30 g/day.

12 . The method of claim 1 , wherein the amount of phosphatidyl serine ranges from 20 mg/day to 600 mg/day, the amount of choline ranges from 20 mg/day to 600 mg/day, and the amount of oleic acid ranges from 0.1 g/day to 30 g/day.

13 . (canceled)

14 . The method of claim 1 , wherein the amount of phosphatidyl serine ranges from 50 mg/day to 300 mg/day, the amount of choline ranges from 50 mg/day to 550 mg/day, and the amount of oleic acid ranges from 0.5 g/day to 25 g/day.

15 . The method of claim 1 , wherein the composition is administered to the subject every day for at least two weeks.

16 . The method of claim 1 , wherein the cognitive performance that is improved is memory.

17 . The method of claim 1 , wherein the cognitive performance that is improved is intelligence.

18 . The method of claim 2 , wherein the human is an elderly human.

19 . The method of claim 18 , wherein the elderly human has been diagnosed with dementia or cognitive dysfunction.

20 .- 29 . (canceled)

30 . A nutritional composition comprising phosphatidyl serine, choline, oleic acid, at least one source of carbohydrate, and at least one source of protein.

31 . The nutritional composition of claim 30 , wherein the composition further comprises at least one source of fat.

32 . The nutritional composition of claim 30 , wherein the composition provides 150-500 calories per serving and is in the form of a powder suitable for reconstitution to a liquid, a liquid or a bar.

33 . (canceled)

34 . (canceled)

35 . The nutritional composition of claim 30 , wherein the composition comprises from 10 mg to 300 mg of phosphatidyl serine per serving.

36 . The nutritional composition of claim 30 , wherein the composition comprises from 10 mg to 300 mg of choline per serving.

37 . (canceled)

38 . The nutritional composition of claim 30 , wherein the composition comprises from 0.1 grams to 15 grams of oleic acid per serving.

39 . (canceled)

40 . The nutritional composition of claim 30 , wherein the composition comprises from 10 mg to 300 mg of phosphatidyl serine, from 10 mg to 300 mg of choline, and from 0.1 grams to 15 grams of oleic acid per serving.

41 . (canceled)

Assignees

• Abbott Lab

Inventors

• Vazhappilly Rema
• Das Tapas

Classifications

• A61P25/28

  for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia · CPC title

• A23L33/105

  Plant extracts, their artificial duplicates or their derivatives · CPC title

• A61K31/685 Primary

  one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin · CPC title

• A23L33/40

  Complete food formulations for specific consumer groups or specific purposes, e.g. infant formula · CPC title

• A61K31/14

  Quaternary ammonium compounds, e.g. edrophonium, choline (betaines A61K31/205) · CPC title