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Cysteine engineered antibodies and conjugates
US2016130358A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016130358-A1 |
| Application number | US-201514851348-A |
| Country | US |
| Kind code | A1 |
| Filing date | Sep 11, 2015 |
| Priority date | Sep 12, 2014 |
| Publication date | May 12, 2016 |
| Grant date | — |
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- Title
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Abstract
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Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.
First claim
Opening claim text (preview).
1 . A cysteine engineered antibody comprising a cysteine amino acid in the heavy chain selected from the group consisting of T114C, A140C, L174C, L179C, T187C, T209C, V262C, G371C, Y373C, E382C, S424C, N434C and Q438C according to EU numbering, or a cysteine amino acid in the light chain selected from the group consisting of I106C, R108C, R142C, and K149C according to Kabat numbering. 2 . The cysteine engineered antibody of claim 1 , wherein the cysteine engineered antibody comprises a sequence selected from the group consisting of: HC-T114C SEQ ID NO.: 5 QGTLV C VSSAS, HC-A140C SEQ ID NO.: 6 TSGGT C ALGCL, HC-L174C SEQ ID NO.: 7 TFPAV C QSSGL, HC-L179C SEQ ID NO.: 8 LQSSG C YSLSS, HC-T187C SEQ ID NO.: 9 LSSVV C VPSSS, HC-T209C SEQ ID NO.: 10 HKPSN C KVDKK, HC-V262C SEQ ID NO.: 11 PEVTC C VVDVS, HC-G371C SEQ ID NO.: 12 TCLVK C FYPSD, HC-Y373C SEQ ID NO.: 13 LVKGF C PSDIA, HC-E382C SEQ ID NO.: 14 IAVEW C SNGQP, HC-S424C SEQ ID NO.: 15 QGNVF C CSVMH, HC-N434C SEQ ID NO.: 16 HEALH C HYTQK, HC-Q438C SEQ ID NO.: 17 HNHYT C KSLSL, LC-I106C SEQ ID NO.: 1 GTKVE C KRTVA, LC-R108C SEQ ID NO.: 2 KVEIK C TVAAP, LC-R142C SEQ ID NO.: 3 NNFYP C EAKVQ, and LC-K149C SEQ ID NO.: 4 AKVQW C VDNAL.
Assignees
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Classifications
Antineoplastic agents · CPC title
Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin · CPC title
- C07K16/32Primary
against translation products of oncogenes · CPC title
- C07K16/18Primary
against material from animals or humans · CPC title
comprising antibodies · CPC title
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- What does patent US2016130358A1 cover?
- Cysteine engineered antibodies comprising a free cysteine amino acid in the heavy chain or light chain are prepared by mutagenizing a nucleic acid sequence of a parent antibody and replacing one or more amino acid residues by cysteine to encode the cysteine engineered antibody; expressing the cysteine engineered antibody; and isolating the cysteine engineered antibody.
- Who is the assignee on this patent?
- Genentech Inc
- What technology area does this patent fall under?
- Primary CPC classification C07K16/32. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Thu May 12 2016 00:00:00 GMT+0000 (Coordinated Universal Time) (A1). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).