Capillary dialyzers

Patent metadata

Field	Value
Publication number	US-2016129172-A1
Application number	US-201414893688-A
Country	US
Kind code	A1
Filing date	Jun 19, 2014
Priority date	Jun 20, 2013
Publication date	May 12, 2016
Grant date	—

Abstract

The present disclosure relates to capillary dialyzers for blood purification comprising from 85-95% crimped fibres and from 5-15% non-crimped fibres.

First claim

1 . A capillary dialyzer comprising a housing and a bundle of semi-permeable hollow fiber membranes disposed therein, characterized in that the bundle of hollow fiber membranes comprises from 85 to 95% crimped fibers and from 5 to 15% non-crimped fibers, relative to the total number of fibers in the bundle.

2 . The capillary dialyzer of claim 1 , wherein the bundle of hollow fiber membranes comprises from 88 to 92% crimped fibers and from 8 to 12% non-crimped fibers.

3 . The capillary dialyzer of claim 1 , wherein the packing density of the hollow fiber membranes in the dialyzer is 55 to 65%.

4 . The capillary dialyzer of claim 1 , wherein the fibers have a sinusoidal texture with a wavelength in the range of from 6 to 9 mm.

5 . The capillary dialyzer of claim 4 , wherein the amplitude of the sinusoidal texture is in the range of from 0.1 to 0.5 mm.

6 . The capillary dialyzer of claim 1 , wherein the hollow fiber membranes have an outer diameter of from 150 to 320 μm.

7 . The capillary dialyzer of claim 1 , wherein the fiber bundle in the dialyzer has a diameter of from 20 to 50 mm.

8 . The capillary dialyzer of claim 1 , wherein the effective fiber length within the bundle is in the range of from 120 to 280 mm.

9 . The capillary dialyzer of claim 1 , wherein the effective membrane surface area of the hollow fiber membranes within the dialyzer is in the range of from 0.25 to 2.5 m 2 .

10 . The capillary dialyzer of claim 9 , wherein the effective membrane surface area of the hollow fiber membranes within the dialyzer is in the range of from 1.1 to 2.1 m 2 .

11 . The capillary dialyzer of claim 1 , wherein the semi-permeable hollow fiber membranes comprise 80-99 wt % of polysulfone or polyethersulfone ; and 1-20 wt % of polyvinylpyrrolidone.

12 . The capillary dialyzer of claim 1 , wherein the semi-permeable hollow fiber membranes comprise a polyamide.

13 . The capillary dialyzer of claim 1 , wherein the semi-permeable hollow fiber membranes comprise a copolymer of acrylonitrile and sodium methallyl-sulfonate .

14 . The capillary dialyzer of claim 1 , wherein the semi-permeable hollow fiber membranes comprise a polyacrylonitrile.

Assignees

• Gambro Lundia Ab

Inventors

• Hornung Markus
• Wochner Arnd
• Buck Reinhold
• Hildwein Helmut
• Kanarjow Nikolaus

Classifications

• A61M1/1621 Primary

  Constructional aspects thereof (semi-permeable membranes for separation processes characterised by their properties B01D69/00; semi permeable membranes characterised by their material B01D71/00) · CPC title

• B01D69/08 Primary

  Hollow fibre membranes (manufacture of hollow fibres D01D5/24, D01F1/08) · CPC title

• B01D69/084

  Undulated fibres · CPC title

• B01D61/243

  Dialysis · CPC title

• B01D69/081

  characterised by the fibre diameter · CPC title