COMBINED ANTI-ACID-FAST BACTERIAL AGENT, SCREENING METHOD FOR ANTI-ACID-FAST BACTERIAL AGENTS, AND ACTIVITY INHIBITOR OF WecA OR ORTHOLOG THEREOF

Patent metadata

Field	Value
Publication number	US-2016129035-A1
Application number	US-201414895719-A
Country	US
Kind code	A1
Filing date	Jun 3, 2014
Priority date	Jun 4, 2013
Publication date	May 12, 2016
Grant date	—

Abstract

A drug combination against acid-fast bacillus , including: an inhibitor for WecA or an ortholog thereof; and at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor, wherein the inhibitor for WecA or an ortholog thereof is used in combination with the at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor; a screening method for a drug against acid-fast bacillus ; and an inhibitor for WecA or an ortholog thereof.

First claim

1 . A method for treating an individual infected with acid-fast bacillus , comprising: administering, to the individual, an inhibitor for WecA or an ortholog thereof, and at least one of an inhibitor for MurX or an ortholog thereof and an RNA synthesis inhibitor.

2 . The method according to claim 1 , wherein the inhibitor for WecA or an ortholog thereof contains a compound expressed by the following Structural Formula (1), and the inhibitor for MurX or an ortholog thereof contains a compound expressed by the following Structural Formula (2):

where in Structural Formula (2), “Me” is a methyl group.

3 . The method according to claim 1 , wherein the inhibitor for WecA or an ortholog thereof contains tunicamycin, and the RNA synthesis inhibitor contains rifampicin.

4 . A screening method for a drug against acid-fast bacillus , the method comprising:
measuring activity of a test substance against WecA or an ortholog thereof.

5 . A method for inhibiting WecA or an ortholog thereof, comprising:
administering a compound expressed by the following Structural Formula (1):

Assignees

• Univ Colorado State Res Found
• Microbial Chem Res Found

Inventors

• Ishizaki Yoshimasa
• Igarashi Masayuki
• Brennan Patrick Joseph
• Crick Dean Calvin

Classifications

• C07H19/067

  with ribosyl as the saccharide radical · CPC title

• A61K31/496

  Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin · CPC title

• A61P31/06

  for tuberculosis · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title

• A61K31/551

  having two nitrogen atoms, e.g. dilazep · CPC title