Muscle preservation in overweight or obese adult during weight loss program

Patent metadata

Field	Value
Publication number	US-2016128372-A1
Application number	US-201314897176-A
Country	US
Kind code	A1
Filing date	Jun 10, 2013
Priority date	Jun 10, 2013
Publication date	May 12, 2016
Grant date	—

Abstract

The invention pertains to the use of a composition comprising per serving between 50-300 kcal; between 10 g and 35 g proteinaceous matter; and at least 2.5 microgram vitamin D, for the manufacture of a nutritional product for (a) the treatment or prevention of muscle mass decrease, (b) stimulation of muscle mass increase; or (d) stimulating muscle mass preservation, in obese or overweight adults of at least 40 years of age participating in a weight loss program. The inventors surprisingly found that nutritional supplementation with a low-caloric composition rich in protein, particularly whey protein and leucine, compared to an iso-caloric control supplement without protein, synergistically leads to preservation of muscle mass during a weight loss program involving a hypocaloric diet and a resistance exercise program in overweight/obese older adult.

First claim

1 .- 19 . (canceled)

20 . A method for preserving muscle mass or stimulation of muscle mass increase or reducing the risk of sarcopenia in obese or overweight adults of at least 40 years of age participating in a weight loss program, the method comprising feeding a nutritional composition to the adult in conjunction with a weight loss program, the weight loss program involving a physical exercise regimen which involves resistance exercise and a hypocaloric dietary regimen, wherein the adults are fed 25-100 g dry weight of the nutritional composition daily, wherein the nutritional composition has an energy density of between 200 and 500 kcal per 100 g dry weight, and in terms of dry weight of the composition; between 45 and 55 wt % proteinaceous matter, comprising 50-95 wt % whey protein, based on total proteinaceous matter, and including between 0.5 and 4 wt % leucine as free amino acid, peptide and/or salt, less than 50 wt % carbohydrates, between 5 and 75 microgram vit D, and optionally between 2 and 15 wt % dietary fiber comprising galactooligosaccharides (GOS), fructooligosaccharides (FOS) and/or pectin oligosaccharides, the composition given to the adults in conjunction with the physical exercise regimen and hypocaloric dietary regimen.

21 . The method according to claim 20 , wherein the nutritional composition comprises per serving between 50 and 300 kcal.

22 . The method according to claim 20 , wherein in the nutritional composition comprises per serving between 10 g and 35 g proteinaceous matter comprising 50-95 wt % whey protein and at least 13 wt % leucine, based on proteinaceous matter; and at least 2.5 microgram vitamin D.

23 . The method according to claim 20 , for the treatment or prevention of muscle mass decrease, or stimulation of muscle mass preservation.

24 . The method according to claim 20 , wherein the adults suffer from a disease or condition selected from the group consisting of sarcopenia, obesity, sarcopenic obesity, pre-diabetes type 2, diabetes type 2, pre-frailty or frailty.

25 . The method according to claim 20 , wherein the hypocaloric dietary regimen comprises a daily energy uptake of less than the daily energy expenditure (TEE) of the adults.

26 . The method according to claim 20 , wherein the treatment comprises a daily dose of 1 to 4 servings.

27 . The method according to claim 20 , wherein the hypocaloric dietary regimen comprises a daily energy uptake of less than the daily energy expenditure (TEE) of the adult of at least 40 years of age, wherein TEE is assessed by means of the doubly labeled water method (TEEDLW).

28 . The method according to claim 27 , wherein the hypocaloric dietary regimen provides 50-95% of the TEE of the obese or overweight adult.

29 . The method according to claim 28 , wherein the hypocaloric dietary regimen provides 60-90% of the TEE of the obese or overweight adult.

30 . The method according to claim 29 , wherein the hypocaloric dietary regimen provides 70-90% of the TEE of the obese or overweight adult.

31 . The method according to claim 20 , wherein the serving is administered as a single shot wherein the serving is consumed within 15 minutes.

32 . The method according to claim 31 , wherein the serving is administered as a single shot wherein the serving is consumed within 10 minutes.

33 . The method according to claim 32 , wherein the serving is administered as a single shot wherein the serving is consumed within 5 minutes.

34 . The method according to claim 20 , wherein between 13 and 20 wt % of the total proteinaceous matter is leucine.

35 . The method according to claim 20 , wherein the composition comprises per serving at least 0.5 gram of at least one compound selected from the group consisting of free leucine, salts of free leucine, or metabolites of leucine, or salts of metabolites of leucine.

36 . The method according to claim 35 , wherein the metabolite is selected from the group consisting of β-hydroxy-β-methylbutyrate, β-hydroxy-β-methylbutyrate free acid, calcium-β-hydroxy-β-methylbutyrate, hydroxyl iso caproic acid and ketoisocaproic acid.

37 . The method according to claim 20 , wherein the free leucine, salts thereof or its metabolites are encapsulated.

38 . The method according to claim 20 , wherein the composition further comprises at least 20en % carbohydrates and/or fat.

39 . The method according to claim 20 , wherein the carbohydrate comprises of at least 10 wt % based on the total carbohydrate matter of a carbohydrate with a glycemic index below 70.

40 . The method according to claim 20 , wherein the fat source comprises at least 30 weight % of unsaturated fatty acids and at least 15 weight % of polyunsaturated acids of total fat in the composition.

41 . The method according to claim 20 , wherein the proteinaceous matter comprises at least 60wt % mammalian whey.

42 . The method according to claim 41 , wherein the mammalian whey is bovine whey.

43 . The method according to claim 20 , wherein the carbohydrate comprises dietary fiber.

44 . The method according to claim 43 , wherein the serving comprises between 0.5 and 6 gram dietary fiber comprising at least one fiber selected from the group consisting of galactooligosaccharides (GOS), fructooligosaccharides (FOS), inulin and pectin oligosaccharides.

Assignees

• Nutricia Nv

Inventors

• Weijs Peter Johan Marie
• De Vogel Johan
• Verlaan George
• Jourdan Marion

Classifications

• A23L33/30 Primary

  Dietetic or nutritional methods, e.g. for losing weight (A23L33/10 takes precedence) · CPC title

• A23L33/175

  Amino acids · CPC title

• A23V2002/00

  Food compositions, function of food ingredients or processes for food or foodstuffs · CPC title

• A23L33/21

  Addition of substantially indigestible substances, e.g. dietary fibres · CPC title

• A23L33/19

  Dairy proteins · CPC title