Compositions for use in cartilage breakdown

Patent metadata

Field	Value
Publication number	US-2016120891-A1
Application number	US-201414894602-A
Country	US
Kind code	A1
Filing date	May 28, 2014
Priority date	May 29, 2013
Publication date	May 5, 2016
Grant date	—

Abstract

The present invention relates to use of a composition comprising oleuropein and/or hydroxytyrosol for maintenance joint health or prevention or treatment of joint disorders. In particular, the invention relates to oleuropein for use to prevent or treat cartilage breakdown.

First claim

1 . A method for preventing or treating cartilage breakdown comprising administering to an individual in need of same a composition comprising oleuropein and/or hydroxytyrosol.

2 . Method according to claim 1 , wherein the composition further comprises curcumin.

3 . Method according to claim 1 , wherein the composition further comprises quercetin.

4 . Method according to claim 1 , wherein the composition further comprises at least one compound selected from the group consisting of antioxidants, anti-inflammatory compounds, glycosaminoglycans, prebiotics, fibres, probiotics, fatty acids, minerals, trace elements and vitamins.

5 . Method according to claim 1 , wherein the composition further comprises at least one anti-inflammatory compound.

6 . Method according to claim 5 , wherein the at least one anti-inflammatory compound is a plant extract.

7 . Method according to claim 6 wherein the plant extract is a plant selected from the group consisting of devil's claw ( Harpagophytum procumbens ), Rosmarinus officinalis , hyssop, ginger ( Zingiber officinale ), turmeric ( Curcuma longa ), Arnica Montana, willow bark, pomegranate ( Punica granatum ), green tea ( Camellia sinensis ), cat's claw ( Uncaria tometosa and Uncaria guianensis ), Indian olibaum ( Boswelia serrata ), and pineapple bromelain ( Ananas comosus ), Black seed ( Nigella sativa ), St. John's wort, hyperforin, Goldenseal, and German Chamomile ( Matricaria recutita ).

8 . Method according to claim 1 , wherein the composition further comprises at least one antioxidant.

9 . Method according to claim 8 wherein the at least one antioxidant is selected from the group consisting of astaxanthin, carotenoids, coenzyme Q(“CoQ 10”), flavonoids, glutathione, Goji (wolfberry), hesperidin, lactowolfberry, lignan, lutein, lycopene, polyphenols, selenium, vitamin A, vitamin C, vitamin E, and zeaxanthin.

10 . Method according to claim 1 , wherein the composition is a nutritional composition.

11 . Method according to claim 1 , wherein the composition is a pharmaceutical composition.

12 . -Method according to claim 10 , wherein the nutritional composition is a medical food.

13 . Method according to claim 1 , wherein the use-method is to inhibit or decrease breakdown of collagen in cartilage.

14 - 15 (canceled)

16 . Method according to claim 1 wherein the method is to maintain or improve activity and/or mobility of an individual.

17 . Method according to claim 1 wherein the method is to decrease joint pain.

Assignees

• Nestec Sa

Inventors

• Horcajada Marie Noelle
• Membrez Fanny
• Offord Cavin Elizabeth

Classifications

• A61P39/06

  Free radical scavengers or antioxidants · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61K31/353

  3,4-Dihydrobenzopyrans, e.g. chroman, catechin · CPC title

• A61P19/08

  for bone diseases, e.g. rachitism, Paget's disease · CPC title