Cavity-filling biopsy site markers

Patent metadata

Field	Value
Publication number	US-2016120510-A1
Application number	US-201614995667-A
Country	US
Kind code	A1
Filing date	Jan 14, 2016
Priority date	Feb 2, 1999
Publication date	May 5, 2016
Grant date	—

Abstract

A mass includes particles that exhibit an in vivo lifetime and that include a bioresorbable material and bubble cavities disposed in the particles, wherein the bubble cavities have length, width, and height dimensions at least one of which is less than or equal to about 2000 microns. The mass exhibits enhanced detectability by ultrasound energy during the lifetime; the lifetime begins upon exposure to in vivo fluids and ends between about 2 and about 20 weeks afterward; and a zero or non-zero fluid-to-solid ratio.

First claim

1 - 75 . (canceled)

76 . A mass comprising:
particles that exhibit an in vivo lifetime and that include a bioresorbable material and bubble cavities disposed in the particles,
wherein
the bubble cavities have length, width, and height dimensions at least one of which is less than or equal to about 2000 microns;
the mass exhibits enhanced detectability by ultrasound energy during the lifetime;
the lifetime begins upon exposure to in vivo fluids and ends between about 2 and about 20 weeks afterward;
and
a zero or non-zero fluid-to-solid ratio.

77 . The mass of claim 76 wherein the lifetime ends between about 6 and about 12 weeks afterward.

78 . The mass of claim 77 wherein all of the length, width, and height dimensions are less than or equal to about 2000 microns.

79 . The mass of claim 78 wherein all of the length, width, and height dimensions are between about 10 and about 500 microns.

80 . The mass of claim 79 wherein all of the length, width, and height dimensions are between about 20 and about 200 microns.

81 . The mass of claim 78 having a volume between about 0.2 and about 1.2 ml.

82 . The mass of claim 81 having a volume of about 0.5 ml.

83 . The mass of claim 81 wherein the bioresorbable material comprises a bioresorbable polymeric material.

84 . The mass of claim 83 wherein the bioresorbable polymeric material comprises polymers, copolymers, polymer alloys, polymer mixtures, or other combinations of poly(esters), poly(hydroxy acids), poly(lactones), poly(amides), poly(ester-amides), poly(amino acids), poly(anhydrides), poly(orthoesters), poly(carbonates), poly(phosphazines), poly(thioesters), poly(urethanes), poly(ester urethanes), polysaccharides, polylactic acids, polyglycolic acids, polycaproic acids, polybutyric acids, or polyvaleric acids.

85 . The mass of claim 84 wherein the bioresorbable polymeric material:
comprises polymers, copolymers, polymer alloys, polymer mixtures, or other combinations of polyglycolic acids, polylactic acids, and polycaproic acids
and
has an average molecular weight of less than about 60 kD.

86 . The mass of claim 85 wherein the bioresorbable material comprises about 65% by weight polylactic acid and about 35% by weight polyglycolic acid.

87 . The mass of claim 83 further comprising less than or equal to 10% by weight of a blowing agent.

88 . The mass of claim 87 further comprising less than or equal to 5% by weight of a blowing agent.

89 . The mass of claim 88 further comprising less than or equal to 2% by weight of a blowing agent.

90 . The mass of claim 89 wherein the blowing agent comprises any one or any combination of sodium bicarbonate, ammonium carbonate, sodium boron hydride, silicon oxy-hydride, hydrochlorofluorocarbon compounds, chlorofluorocarbon compounds, mixtures of sodium bicarbonate, ammonium carbonate, sodium boron hydride, silicon oxy-hydride, hydrochlorofluorocarbon compounds, and chlorofluorocarbon compounds, hexane, heptane, heptene, propyl alcohol, or isopropyl alcohol.

91 . The mass of claim 90 wherein the blowing agent comprises sodium bicarbonate.

92 . The mass of claim 87 further comprising a binding agent.

93 . The mass of claim 92 wherein the binding agent comprises gelatin, polyethylene glycol, polyvinyl alcohol, glycerin, acrylic hydrogels, organic hydrogels, or their combinations.

94 . The mass of claim 92 comprises gelatin in a weight proportion of about 1 part gelatin to between about 2 parts polymeric material to about 5 parts polymeric material.

95 . The mass of claim 94 wherein the weight proportion of about 1 part gelatin to between about 1 part polymeric material to about 3 parts polymeric material.

96 . The mass of claim 95 wherein gelatin comprises bovine collagen, porcine collagen, ovine collagen, equine collagen, synthetic collagen, agar, synthetic gelatin, or their combinations.

97 . The mass of claim 94 further comprising a magnetic resonance imaging (MRI) agent, a colorant, a radioactive material, or a radiopaque material.

98 . The mass of claim 97 comprising a radiopaque marker formed in a recognizable shape not naturally found within a patient's body.

99 . The mass of claim 97 further comprising a biocompatible liquid.

100 . The mass of claim 99 wherein the biocompatible liquid comprises any one or any combination of sterile saline, sterile saline containing an pharmaceutical agent, sterile saline containing an anesthetic agent, sterile saline containing a hemostatic agent, sterile saline containing a colorant, sterile saline containing a radio contrast agent, sterile saline containing an osmotic agent, sterile sugar solution, sterile sugar solution containing a pharmaceutical agent, sterile sugar solution containing an anesthetic agent, sterile sugar solution containing a hemostatic agent, sterile sugar solution containing a colorant, sterile sugar solution containing a radio contrast agent, biocompatible oils, biocompatible oils containing an pharmaceutical agent, biocompatible oils containing an anesthetic agent, biocompatible oils containing a hemostatic agent, biocompatible oils containing a colorant, biocompatible oils containing a radio contrast agent, adrenochrome, algin, alginic acid, aminocaproic acid, batroxobin, carbazochrome salicylate, cephalins, cotarmine, ellagic acid, epinephrine, ethamsylate, factor VIII, factor IX, factor XIII, fibrin, fibrinogen, naphthoquinone, oxamarin, oxidized cellulose, styptic collodion, sulamrin, thrombin, thromboplastin (factor III), tolonium chloride, tranexamic acid, or vasopression.

101 . The system of claim 100 wherein said biocompatible liquid comprises a pharmaceutical agent selected from the group consisting of penicillins, cephalosporins, vancomycins, aminoglycosides, quinolones, polymyxins, erythromycins, tetracyclines, streptomycins, sulfa drugs, chloramphenicols, clindamycins, lincomycins, sulfonamides, paclitaxel, docetaxel, acetyl sulfisoxazole, alkylating agents, antimetabolites, plant alkaloids, mechlorethamine, chlorambucil, cyclophosphamide, melphalan, ifosfamide, methotrexate, 6-mercaptopurine, 5-fluorouracil, cytarabine, vinblastine, vincristine, etoposide, doxorubicin, daunomycin, bleomycin, mitomycin, carmustine, lomustine, cisplatin, interferon, asparaginase, tamoxifen, flutamide, amantadines, rimantadines, ribavirins, idoxuridines, vidarabines, trifluridines, acyclovirs, ganciclovirs, zidovudines, foscarnets, interferons, prochlorperzine edisylate, ferrous sulfate, aminocaproic acid, mecamylamine hydrochloride, procainamide hydrochloride, isoproterenol sulfate, phenmetrazine hydrochloride, bethanechol chloride, methacholine chloride, isopropamide iodide, tridihexethyl chloride, phenformin hydrochloride, methylphenidate hydrochloride, theophylline cholinate, cephalexin hydrochloride, diphenidol, meclizine hydrochloride, prochlorperazine maleate, phenoxybenzamine, thiethylperzine maleate, anisindone, diphenadione erythrityl tetranitrate, isoflurophate, acetazolamide, methazolamide, bendroflumethiazide, chloropromaide, tolazamide, chlormadinone acetate, phenaglycodol, allopurinol, aluminum aspirin, hydrocortisone, hydrocorticosterone acetate, cortisone acetate, dexamethasone and its derivatives such as betamethasone, triamcinolone, methyltestosterone, 17-S-estradiol, ethinyl estradiol, ethinyl estradiol 3-methyl ether, prednisolone, 17-hydroxyprogesteron

Assignees

• Senorx Inc

Inventors

• Burbank Fred H
• Lubock Paul
• Jones Michael L

Classifications

• A61B2090/3925

  ultrasonic · CPC title

• A61M37/0069

  Devices for implanting pellets, e.g. markers or solid medicaments (for introducing of radioactive sources for interstitial radiation therapy, i.e. brachytherapy A61N5/1027) · CPC title

• A61B10/02

  Instruments for taking cell samples or for biopsy {(A61B10/0038 and A61B10/0045 take precedence; needle locating or guiding means A61B17/3403; samplers for enzymology or microbiology C12M1/26; sampling or preparing biological specimens G01N33/48)} · CPC title

• A61B2090/392

  Radioactive markers · CPC title

• A61B8/481 Primary

  involving the use of contrast agents, e.g. microbubbles introduced into the bloodstream · CPC title