Polyvalent hiv-1 immunogen

Patent metadata

Field	Value
Publication number	US-2016115205-A1
Application number	US-201414784496-A
Country	US
Kind code	A1
Filing date	Apr 15, 2014
Priority date	Apr 15, 2013
Publication date	Apr 28, 2016
Grant date	—

Abstract

The present invention relates, in general, to human immunodeficiency virus-1 (HIV-1) particular, to a polyvalent vaccine for HIV-1 and to methods of making and using same.

First claim

What is claimed is:

1 . A composition comprising an HIV-1 envelope AA104.0 ( FIG. 6 , SEQ ID NO: 1), AA107.0 ( FIG. 6 , SEQ ID NO: 2), AA058.1 ( FIG. 6 , SEQ ID NO:3), or a combination thereof.

2 . The composition of claim 1 comprising AA104.0 (SEQ ID NO: 1), AA107.0 (SEQ ID NO: 2) and AA058.1(SEQ ID NO:3).

3 . The composition of claim 1 or 2 , wherein the envelope is a gp120Delta N-terminus polypeptide from SEQ ID NOs: 1, 2 or 3.

4 . The composition of any one of claims 1 - 3 , further comprising HIV-1 envelope B.6240 gp120D11 and A244 gp120 D11.

5 . A composition comprising the gp120Delta N-terminus polypeptide from AA104.0 ( FIG. 6 , SEQ ID NO: 1), AA107.0 ( FIG. 6 , SEQ ID NO: 2), AA058.1 ( FIG. 6 , SEQ ID NO: 3), B.6240 gp120D11 and A244 gp120 D11.

6 . The composition of any one of claims 1 - 5 , wherein the envelope is a recombinant protein.

7 . A composition comprising a nucleic acid encoding any one of envelopes of AA104.0 ( FIG. 6 , SEQ ID NO: 1), AA107.0 ( FIG. 6 , SEQ ID NO: 2), AA058.1 ( FIG. 6 , SEQ ID NO: 3), or the gp120Delta N-terminus polypeptide therefrom.

8 . The composition of claims 1 - 5 further comprising an adjuvant.

9 . The composition of claim 8 , wherein the adjuvant is a Toll-like receptor 4 agonist glucopyranosyl lipid adjuvant-stable emulsion (GLA/SE).

10 . A method of inducing an immune response in a subject comprising administering to the subject the composition of any one of claim 1 or 5 in an amount sufficient to effect the induction.

11 . The method of claim 10 wherein the composition is administered as a boost.

Assignees

• Univ Duke
• Government Of The U S As Represented By The Secretary Of The Army On Behalf Of Walter Reed A
• Jackson H M Found Military Med
• Los Alamos Nat Security Llc

Inventors

• Kim Jerome
• Rolland Morgane
• Korber Bette T
• Haynes Barton F

Classifications

• A61P31/18

  for HIV · CPC title

• A61K2039/70

  Multivalent vaccine · CPC title

• A61K39/12

  Viral antigens · CPC title

• C12N2740/16134

  Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein · CPC title

• C07K14/005 Primary

  from viruses · CPC title