High efficiency continuous-flow production of radioisotopes
US-2017337998-A1 · Nov 23, 2017 · US
US2016111176A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016111176-A1 |
| Application number | US-201514949665-A |
| Country | US |
| Kind code | A1 |
| Filing date | Nov 23, 2015 |
| Priority date | Feb 10, 2010 |
| Publication date | Apr 21, 2016 |
| Grant date | — |
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The invention provides for a method for producing isotopes using a beam of particles from an accelerator, whereby the beam is maintained at between about 70 to 2000 MeV; and contacting a thorium-containing target with the particles. The medically important isotope 225 Ac is produced via the nuclear reaction (p,2p6n),whereby an energetic proton causes the ejection of 2 protons and 6 neutrons from a 232 Th target nucleus. Another medically important isotope 213 Bi is then available as a decay product. The production of highly purified 211 At is also provided.
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1 . A method for producing astatine isotope, the method comprising: a. irradiating a thorium target for a time and at an energy sufficient to produce radon isotopes; b. extracting the radon isotopes from the target; c. condensing and purifying the extracted radon isotopes; and d. generating At from the purified radon isotopes. 2 . The method as recited in claim 1 wherein the target is irradiated with protons maintained at an energy of about 100 to 400 MeV. 3 . The method as recited in claim 1 wherein 211 At is generated from the decay of 211 Rn and chemically separated from radon gas. 4 . The method as recited in claim 1 wherein the step of extracting the radon isotopes from the target comprises heating the irradiated target. 5 . The method as recited in claim 1 wherein the radon is extracted along with co-extractants as a gas mixture and the step of purifying the radon comprises subjecting the gas mixture to a cold trap to separate the co-extractants from radon. 6 . The method as recited in claim 5 wherein the radon remains in vapor phase. 7 . The method as recited in claim 1 wherein the radon is continuously extracted from the target.
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