Apparatus and methods for drug delivery using multiple reservoirs

Patent metadata

Field	Value
Publication number	US-2016106584-A1
Application number	US-201414894161-A
Country	US
Kind code	A1
Filing date	May 30, 2014
Priority date	Jun 3, 2013
Publication date	Apr 21, 2016
Grant date	—

Abstract

A cartridge, including a first member that defines an inner volume and a second member disposed therein, is disposed in a housing. A first reservoir is disposed in the inner volume in a position distal to the second member. The first member is partially disposed in a second reservoir, defined by the housing. The second member is configured to be moved from a first position, in which the first reservoir contains a drug and the second reservoir is fluidically isolated from the inner volume, toward a second position, in which the first reservoir and the second reservoir are in fluid communication with the inner volume, such that the second reservoir receives a volume of the drug from the first reservoir. The first member and the second member are collectively moved relative to the second reservoir to expel the volume of the drug from the second reservoir.

First claim

What is claimed:

1 . An apparatus, comprising:
a housing; a cartridge assembly, at least a portion of the cartridge assembly configured to be movably disposed in the housing, the cartridge assembly including a first movable member and a second movable member, the first movable member defining an inner volume, at least a portion of the second movable member being movably disposed in the inner volume between a first position and a second position relative to the first movable member; a first reservoir disposed within the inner volume such that the first reservoir is disposed in a distal position relative to the second movable member, the first reservoir containing a drug when the second movable member is in its first position relative to the first movable member, the first reservoir being placed in fluid communication with the inner volume when the second movable member is in its second position relative to the first movable member; and a second reservoir at least partially defined by the housing, a portion of the first movable member being movably disposed in the second reservoir, the second reservoir being fiuidically isolated from the inner volume when the second movable member is in its first position relative to the first movable member, the second reservoir being placed in fluid communication with the inner volume when the second movable member is moved toward its second position relative to the first movable member to receive a volume of the drug from the first reservoir, the first movable member and the second movable member collectively configured to be moved from a first position relative to the housing to a second position relative to the housing to expel the volume of the drug from the second reservoir.

2 . The apparatus of claim 1 , wherein the housing has a proximal end portion and a distal end portion, the proximal end portion defining an opening to receive at least a portion of the cartridge assembly, the distal end portion being physically and fluidically coupled to a puncture member, the puncture member being in fluid communication with the second reservoir.

3 . The apparatus of claim 2 , wherein the puncture member is configured to puncture ocular tissue of a patient.

4 . The apparatus of claim 1 , wherein the second reservoir includes a volumetric indicator.

5 . The apparatus of claim 1 , wherein the first reservoir is a deformable reservoir, the first reservoir including a portion configured to break open when the second movable member is moved toward its second position relative to the first movable member.

6 . The apparatus of claim 1 , wherein the first reservoir is a deformable reservoir, the first reservoir configured to be transitioned from a substantially undeformed configuration, in which the first reservoir contains the drug, to a deformed configuration, in which the volume of the drug is disposed substantially outside of the first reservoir.

7 . The apparatus of claim 6 , wherein the housing includes an inner surface that forms a shoulder configured to be in contact with the first reservoir, the shoulder configured to transition the first reservoir from the substantially undeformed configuration to the deformed configuration in response to the movement of the second movable member from its first position to its second position relative to the first movable member.

8 . The apparatus of claim 1 , further comprising:
a safety tab movably coupled to the housing, the safely tab configured to be placed in contact with first movable member to selectively limit a movement of the first movable member relative to the housing.

9 . The apparatus of claim 1 , wherein the first movable member includes a valve member, the valve member configured to be transitioned from a closed configuration when the second movable member is in its first position relative to the first movable member to a substantially open configuration when the second movable member is moved toward its second position relative to the first movable member, the inner volume being fluidically isolated from the second reservoir when the valve member is in the closed configuration, the inner volume being in fluid communication with the second reservoir when the valve member is in the open configuration.

10 . An apparatus, comprising:
a housing having a distal end portion, the distal end portion defining a substantially rigid reservoir physically and fluidically coupled to a puncture member, the puncture member configured to puncture ocular tissue of a patient; and a cartridge assembly configured to be movably disposed in the housing, the cartridge assembly including a first movable member and a second movable member, at least a portion of the first movable member configured to be disposed in the substantially rigid reservoir, the first movable member having an inner surface forming a shoulder and defining an inner volume, at least a portion of the second movable member being movably disposed in the inner volume between a first position and a second position, the cartridge assembly including a deformable reservoir disposed within the inner volume between the shoulder and the second movable member, the shoulder configured to selectively engage the deformable reservoir when the second movable member is moved relative to the first movable member from its first position to its second position to transition the deformable reservoir from a first configuration, in which a drug is contained within the deformable reservoir, and a second configuration, in which a volume of the drug is disposed substantially outside the deformable reservoir, the substantially rigid reservoir being fluidically isolated from the inner volume when the second movable member is in its first position, the substantially rigid reservoir configured to receive the volume of the drug from the inner volume when the second movable member is moved relative to the first movable member toward its second position, the first movable member of the cartridge assembly being movable relative to the housing front a first position to a second position to deliver the volume of the drug, via the puncture member, from the second reservoir to the ocular tissue.

11 . The apparatus of claim 10 , wherein the shoulder includes at least one protrusion, the at least one protrusion configured to puncture the deformable reservoir to place the deformable reservoir in its second configuration.

12 . The apparatus of claim 10 , wherein the puncture member defines a lumen in fluid communication with the substantially rigid reservoir, the first movable member of the cartridge assembly configured to move relative to the housing from its first position to its second position such that a pressure within the substantially rigid reservoir is sufficient to urge a flow of the drug through the lumen.

13 . The apparatus of claim 10 , wherein the puncture member has a proximal end portion and a distal end portion, the proximal end portion being physically and fluidically coupled to the substantially rigid reservoir, the distal end portion forming a beveled edge, the beveled edge configured to pierce ocular tissue while minimizing deformation at or near the pierce site.

14 . The apparatus of claim 10 , wherein the second movable member is configured to move relative to the first movable member from its first position toward its second position in response to an applied force such that a pressure within the inner volume is increased from a first pressure to a second pressure, the second pressure being sufficient to transition the deformable reservoir from the its first configuration to its second configuration.

Assignees

• Clearside Biomedical Inc

Inventors

• Andino Rafael Victor
• Patel Samirkumar R
• Zarnitsyn Vladimir
• Brooks Christopher John

Classifications

• A61J1/2093

  Containers having several compartments for products to be mixed · CPC title

• A61F9/0017 Primary

  implantable in, or in contact with, the eye, e.g. ocular inserts · CPC title

• A61M5/284

  comprising means for injection of two or more media, e.g. by mixing · CPC title

• A61M5/19

  having more than one chamber {, e.g. including a manifold coupling two parallelly aligned syringes through separate channels to a common discharge assembly (surgical glue applicators A61B17/00491)} · CPC title

• A61M2005/31598

  having multiple telescopically sliding coaxial pistons encompassing volumes for components to be mixed · CPC title