Compositions for use in cartilage breakdown

Patent metadata

Field	Value
Publication number	US-2016101125-A1
Application number	US-201414894085-A
Country	US
Kind code	A1
Filing date	May 28, 2014
Priority date	May 29, 2013
Publication date	Apr 14, 2016
Grant date	—

Abstract

The present invention relates to use of a composition comprising rutin for maintenance of joint health or prevention or treatment of joint disorders. In particular, the invention relates to rutin for use to prevent or treat cartilage breakdown.

First claim

1 - 15 . (canceled)

16 . A method of prevention or treatment of cartilage breakdown, the method comprising administering to an individual in need thereof an effective amount of a composition comprising rutin.

17 . The method of claim 16 , wherein the composition further comprises curcumin.

18 . The method of claim 16 , wherein the composition further comprises at least one compound selected from the group consisting of antioxidants, anti-inflammatory compounds, glycosaminoglycans, prebiotics, fibres, probiotics, fatty acids, minerals, trace elements and vitamins.

19 . The method of claim 16 , wherein the composition further comprises at least one antioxidant.

20 . The method of claim 19 , wherein the at least one antioxidant is selected from the group consisting of astaxanthin, carotenoids, coenzyme Q10 (“CoQ10”), flavonoids, glutathione, Goji (wolfberry), hesperidin, lactowolfberry, lignan, lutein, lycopene, polyphenols, selenium, vitamin A, vitamin C, vitamin E, and zeaxanthin.

21 . The method of claim 16 , wherein the composition further comprises at least one anti-inflammatory compound.

22 . The method of claim 20 , wherein the at least one anti-inflammatory compound is a plant extract.

23 . The method of claim 21 wherein the plant extract is an extract of one or more plants selected from the group consisting of devil's claw ( Harpagophytum procumbens ), Rosmarinus officinalis, hyssop, ginger ( Zingiber officinale ), turmeric ( Curcuma longa ), Arnica Montana, willow bark, pomegranate ( Punica granatum ), green tea ( Camellia sinensis ), cat's claw ( Uncaria tometosa and Uncaria guianensis ), Indian olibaum ( Boswelia serrata ), pineapple bromelain ( Ananas comosus ), Black seed ( Nigella sativa ), St. John's wort, hyperforin, Goldenseal, and German Chamomile ( Matricaria recutita ).

24 . The method of claim 16 , wherein the composition is a nutritional composition.

25 . The method of claim 24 , wherein the nutritional composition is a medical food.

26 . The method of claim 16 , wherein the composition is a pharmaceutical composition.

27 . The method of claim 16 , wherein the composition is administered to provide an amount of the rutin that is effective to inhibit or decrease cartilage breakdown in Osteoarthritis.

28 . The method of claim 16 , wherein the composition comprises rutin and curcumin, and the composition is administered to provide an amount of the rutin and the curcumin that is effective to inhibit hypertrophy of chondrocytes.

29 . A method of manufacturing a nutritional composition for prevention or treatment of cartilage breakdown, the method comprising providing one or more ingredients for a nutritional composition, providing rutin, and mixing the one or more ingredients and the rutin.

30 . The method of claim 29 , comprising mixing curcumin with the one or more ingredients and the rutin.

Assignees

• Nestec Sa

Inventors

• Horcajada Marie Noelle
• Membrez Fanny
• Offord Cavin Elizabeth

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P29/00

  Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] · CPC title

• A61P19/02

  for joint disorders, e.g. arthritis, arthrosis · CPC title

• A61K36/53

  Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender · CPC title

• A61K45/06

  Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca · CPC title