Methods for the preparation of diasteromerically pure phosphoramidate prodrugs

Patent metadata

Field	Value
Publication number	US-2016016980-A1
Application number	US-201514746430-A
Country	US
Kind code	A1
Filing date	Jun 22, 2015
Priority date	Jul 19, 2010
Publication date	Jan 21, 2016
Grant date	—

Abstract

Provided are methods and intermediates for preparing diastereomerically pure phosphoramidate prodrugs of nucleosides of Formulas Ia and Ib:

The compounds of Formula Ia and Ib are useful for the treatment Hepatitis C infections.

First claim

1 - 36 . (canceled)

37 . A compound selected from the group consisting of

or salts or esters thereof.

Assignees

• Gilead Sciences Inc

Inventors

• Cho Aesop
• Clarke Michael O' Neil Hanrahan
• Wolckenhauer Scott Alan

Classifications

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61P31/14

  for RNA viruses · CPC title

• C07H19/10

  with the saccharide radical esterified by phosphoric or polyphosphoric acids · CPC title

• C07H1/06

  Separation; Purification · CPC title

• C07H1/00 Primary

  Processes for the preparation of sugar derivatives · CPC title