Novel heterocycles as modulators of kinase activity

Patent metadata

Field	Value
Publication number	US-2016016936-A1
Application number	US-201414775205-A
Country	US
Kind code	A1
Filing date	Mar 10, 2014
Priority date	Mar 11, 2013
Publication date	Jan 21, 2016
Grant date	—

Abstract

The invention provides novel heterocyclic amines according to Formula (I) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.

First claim

1 . A compound of Formula (I)

wherein:
R 1 is Hal, LA, OH, O(LA), NH 2 and/or NH(LA), N(LA) 2 , NO 2 , CN, OCN, COOH, COO(LA), CONH 2 , CONH(LA), CON(LA) 2 , NHCO(LA), NHCONH(LA), NHCONH 2 , NHSO 2 (LA), CHO, CO(LA),
or a mono- or bicyclic, aliphatic or aromatic homo- or heterocycle having 0, 1, 2, 3 or 4 N and/or O atoms and 4, 5 or 6, 7, 8, 9, or 10 skeleton atoms which may be unsubstituted or, independently of one another, mono-, di- or trisubstituted by Hal, LA, OH, O(LA), NH 2 and/or NH(LA), N(LA) 2 , NO 2 , CN, OCN, COOH, COO(LA), CONH 2 , CONH(LA), CON(LA) 2 , NHCO(LA), NHCONH(LA), NHCONH 2 , CHO and/or CO(LA) or an unbranched or branched linear or cyclic alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 C atoms, in which one or two CH 2 groups may be replaced by an O atom and/or by an —NH—, NH(LA), —CO—, —NHCO— or —CH═CH— group, and/or in which a CH group may be replaced by —N—;

R A is H; or R A and R 1 , together with the atoms to which each is attached, forms a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; which is optionally substituted;
each R 2 is independently Hal, OH or A;
A is unbranched or branched alkyl group having 1, 2, 3, 4, 5 of 6 C atoms in which 1-4 H atoms can be replaced, independently of each other, by Hal;
R 3 H, or an unbranched or branched linear or mono- or bicyclic alkyl group having 1, 2, 3, 4, 5, 6, 7, 8 or 9 C atoms, in which one or two CH 2 groups may be replaced by an —O— or —NH— group, and/or in which one or two CH groups may be replaced by —N— and/or in which 1, 2 or 3 H atoms may be replaced by Hal or OH; or R 3 is unbranched or branched alkyl group having 1, 2, 3, 4, 5 of 6 C atoms, which is substituted by a 3-6 membered heterocyclic ring, which may be further optionally substituted;
R 4 is C 5-10 aryl, a 3-8 membered saturated or partially unsaturated carbocyclic ring, a 3-7 membered heterocylic ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur, or a 5-6 membered monocyclic heteroaryl ring having 1-4 heteroatoms independently selected from nitrogen, oxygen, or sulfur; each of which is mono-, di- or trisubstituted by Hal, LA, OH, O(LA), NH 2 and/or NH(LA), N(LA) 2 , NO 2 , CN, OCN, COOH, COO(LA), CONH 2 , CONH(LA), CON(LA) 2 , NHCO(LA), NHCONH(LA), NHCONH 2 , NHSO 2 (LA), CHO or CO(LA);
LA is an unbranched or branched, saturated or partially unsaturated, linear hydrocarbon chain having 1, 2, 3 or 4 C atoms, wherein 1, 2 or 3 H atoms may be replaced by Hal;
Hal is F, Cl, Br or I; and
n is 1 or 2.

2 . The compound of claim 1 wherein R 1 is CN, CONH 2 , Hal, O(LA), or an unbranched or branched linear or cyclic alkyl having 1, 2, 3, 4, 5, 6, 7 or 8 C atoms, in which one or two CH 2 groups may be replaced by an O atom and/or by an —NH—, NH(LA), —CO—, —NHCO— or —CH═CH— group, and/or in which a CH group may be replaced by —N—.

3 . The compound of claim 2 , wherein R 1 is selected from Table 1.

TABLE 1

Substituents for R 1 in Formula (I):

4 . The compound of claim 1 wherein each R 2 is independently Hal, OH, methyl, ethyl, n-propyl, i-propyl, n-butyl, s-butyl, t-butyl, straight chain or branched pentyl, or straight chain or branched hexyl.

5 . The compound of claim 4 wherein each R 2 is independently F, OH, or methyl.

6 . The compound of claim 1 , wherein R 3 is H.

7 . The compound of claim 1 , wherein R 3 is selected from Table 2:

TABLE 2

Substituents for R 3 in Formula (I):

Assignees

• Lan Ruoxi
• Chen Xiaoling
• Xiao Yufang
• Huck Bayard R
• Goutopoulos Andreas
• Merck Patent Gmbh

Inventors

• Lan Ruoxi
• Chen Xiaoling
• Xiao Yufang
• Huck Bayard R
• Goutopoulos Andreas

Classifications

• A61P35/02

  specific for leukemia · CPC title

• A61P35/00

  Antineoplastic agents · CPC title

• A61P43/00

  Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00 · CPC title

• A61K31/506

  not condensed and containing further heterocyclic rings · CPC title

• A61K31/519 Primary

  ortho- or peri-condensed with heterocyclic rings · CPC title