Composite material

Patent metadata

Field	Value
Publication number	US-2016015852-A1
Application number	US-201514799071-A
Country	US
Kind code	A1
Filing date	Jul 14, 2015
Priority date	Jul 15, 2014
Publication date	Jan 21, 2016
Grant date	—

Abstract

According to embodiments, a composite material is disclosed. The composite material has a multi-layered structure, wherein the multi-layered structure is constituted by a hydrophilic biodegradable polymer and a collagen. In particular, the collagen is strip-shaped and has a fiber length from 1.5 mm to 50 mm. There are at least ten stacked layers per 5 μm of thickness in the multi-layered structure.

First claim

What is claimed is:

1 . A composite material, which has a multi-layered structure constituted by a hydrophilic biodegradable polymer and a collagen, wherein the collagen is strip-shaped and has a fiber length between about 1.5 mm and 50 mm.

2 . The composite material as claimed in claim 1 , wherein there are at least ten stacked layers per 5 μm of thickness in the multi-layered structure.

3 . The composite material as claimed in claim 2 , wherein each stacked layer has a thickness between 0.1 to 1 μm.

4 . The composite material as claimed in claim 1 , wherein the hydrophilic biodegradable polymer comprises polyvinyl alcohol (PVA), polyethylene glycol/polyethylene oxide (PEG/PEO), polyvinylpyrrolidone (PVP), or a combination thereof.

5 . The composite material as claimed in claim 1 , wherein the hydrophilic biodegradable polymer has a molecular weight between 300 and 1,500,000.

6 . The composite material as claimed in claim 1 , wherein the weight ratio between the collagen and the hydrophilic biodegradable polymer is from 1:3 to 9:1.

7 . The composite material as claimed in claim 1 , wherein the composite material has a swelling ratio between 2 and 15.

8 . The composite material as claimed in claim 1 , wherein the composite material has a light transmittance larger than or equal to 90%.

9 . The composite material as claimed in claim 1 , wherein the composite material has a suture pull-out strength between 3 Mpa and 50 Mpa.

10 . A composite material, comprising a product fabricated by the following steps:
a hydrophilic biodegradable polymer into a solvent, obtaining a first solution; adjusting the pH value of the first solution to be lower than or equal to 5; adding a collagen into the first solution, obtaining a second solution, wherein the collagen is strip-shaped and has a fiber length between 1.5 mm and 50 mm; and subjecting the second solution to a drying process, obtaining a film.

11 . The composite material as claimed in claim 10 , wherein the drying process is a biaxial stretching process or solvent casting.

12 . The composite material as claimed in claim 10 , after the drying process, wherein the film is subject to a treatment, such that at least one of the hydrophilic biodegradable polymer and the collagen undergoes a cross-linking reaction.

13 . The composite material as claimed in claim 12 , wherein the treatment is performed in the presence of a cross-linking agent.

14 . The composite material as claimed in claim 13 , wherein the cross-linking agent comprises formaldehyde, glutaraldehyde, glyoxal, malondialdehyde, succinyl dialdehyde, phthalaldehyde, dialdehyde starch, polyacrolein, polymethacrolein, or a combination thereof.

15 . The composite material as claimed in claim 12 , wherein the treatment is performed by irradiating the film with a radiation.

16 . The composite material as claimed in claim 15 , wherein the radiation comprises ultraviolet light, or a Gamma ray.

17 . The composite material as claimed in claim 10 , wherein the hydrophilic biodegradable polymer comprises polyvinyl alcohol, polyethylene glycol/polyethylene oxide, polyvinylpyrrolidone, or a combination thereof.

18 . The composite material as claimed in claim 10 , wherein the hydrophilic biodegradable polymer has a molecular weight between 300 and 1,500,000.

19 . The composite material as claimed in claim 10 , wherein the weight ratio between the collagen and the hydrophilic biodegradable polymer is from 1:3 to 9:1.

20 . The composite material as claimed in claim 10 , wherein the composite material has a swelling ratio between 1 and 15.

21 . The composite material as claimed in claim 10 , wherein the composite material has a light transmittance larger than or equal to 90%.

22 . The composite material as claimed in claim 10 , wherein the composite material has a suture pull-out strength between 3 Mpa and 50 Mpa.

Assignees

• Ind Techology Res Inst
• Ind Tech Res Inst

Inventors

• Liou Yu-Bing
• Wang Hsiu-Ying
• Shen Hsin-Hsin
• Shen Ying-Wen
• Huang Chin-Tsung
• Hsu Hsin-Yi

Classifications

• A61L15/325

  Collagen · CPC title

• A61L15/225

  Mixtures of macromolecular compounds · CPC title

• A61L15/64 Primary

  specially adapted to be resorbable inside the body · CPC title

• A61L15/26

  Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)} · CPC title

• A61L15/24

  Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof {(A61L15/225 takes precedence)} · CPC title