Nano- microdelivery systems for oromucosal delivery of an active ingredient

Patent metadata

Field	Value
Publication number	US-2016015703-A1
Application number	US-201414772462-A
Country	US
Kind code	A1
Filing date	Mar 6, 2014
Priority date	Mar 7, 2013
Publication date	Jan 21, 2016
Grant date	—

Abstract

A composition for oromucosal delivery of at least one active ingredient, more particularly a lipid nano-microdelivery system comprising a nicotine component and/or a flavour component, wherein the nicotine component may be delivered to the oral cavity via absorption through the mucosal membranes thereof and/or wherein the flavour component may be delivered to the oral mucosa by controlled release.

First claim

1 . A composition for oromucosal delivery of at least one active ingredient comprising:
a lipid nano-micro-structure comprising at least one lipid and at least one active ingredient selected from the group consisting of a nicotine component and a flavour component, said at least one active ingredient being immobilised in said lipid nano-micro-structure.

2 . The composition according to claim 1 , wherein said lipid nano-micro-structure is selected from the group comprising lipid nano-microparticles, lipid nano-microfibres, nano-microparticles encapsulated/immobilised in lipid nano-microfibres, lipid nano-microparticles encapsulated/immobilised in polymer nano-microfibers, lipid nano-microparticles encapsulated/immobilised in polymer nano-microparticles, nano-micro structured lipid carriers (N-MLC's), lipid drug conjugate (LDC) nano-microparticles, and polymer-lipid hybrid nano-microparticles (PLNM), and any combinations thereof.

3 . The composition according to claim 1 , wherein said nicotine component is selected from the group consisting of nicotine base and a salt of nicotine.

4 . The composition according to claim 1 , wherein said flavour component is selected from the group consisting of one or more components of vanilla, one or more components of spearmint, one or more components of orange, menthol, one or more components of nutmeg, of one or more components of eucalyptus, one or more components of cinnamon, one or more components of thyme, one or more components of anise, and one or more components of lemon or lime.

5 . The composition according to claim 1 , wherein said lipid nano-microstructure comprises at least one lipid selected from the group consisting of fatty acids, fatty esters and fatty mono-, di-, and triglycerides thereof, partial glycerides, fatty alcohols and their esters and ethers, natural and synthetic waxes, bees wax, carnauba wax, wax alcohols and their esters, hydrogenated vegetable oils, hard paraffins, phospholipids, sterols and sterol derivatives, and mixtures thereof.

6 . The composition according to claim 5 , wherein said at least one lipid is selected from the group consisting of C8-24 fatty acids and C8-24 fatty mono-, di-, or triglycerides.

7 . The composition according to claim 1 further comprising at least one surfactant, wherein said at least one surfactant is selected from the group consisting of ionic, non-ionic, and amphoteric surfactants.

8 . The composition according to claim 7 , wherein the at least one surfactant is present in a ratio of from about 1:0.005 to about 1:10 lipid nano-micro-structure:surfactant.

9 . The composition according to claim 1 , comprising a nicotine and a flavour component, wherein the nicotine component is immobilised in separate lipid nano-micro-structures from the lipid nano-micro-structures immobilising the flavour component.

10 . The composition according to claim 1 further comprising at least one excipient.

11 . The composition according to claim 1 further comprising at least one mucoadhesive compound selected from the group consisting of pectin, chitosan, sodium alginate, polyvinyl alcohol (PVA), polyacrylic acid (PAA), methyl cellulose (MC), sodium carboxy methylcellulose (SCMC), hydroxy propyl cellulose (HPC).

12 . The composition according to claim 1 , wherein said composition is selected from the group consisting of chewing gums, lozenges, strips, orally dispersible powders, mouth sprays, and pouches for oral use.

13 . A method for the preparation of a composition in the form of lipid nano-microparticles according to claim 1 , comprising the steps of:
a) Providing said at least one lipid in a melted state, optionally by heating to above the phase transition temperature thereof or providing said at least one lipid dispersed in a solvent; b) Dissolving said at least one active ingredient in the melted lipid, or in the lipid dispersed in a solvent; c) Optionally adding at least one surfactant, optionally at least one excipient and optionally at least one mucoadhesive compound and optionally at least one porogen compound neat or in a solution thereof; and d) mixing and homogenising to obtain a nano-micro-structure comprising said at least one active ingredient component.

14 . A method for the preparation of a composition in the form of lipid nano-microfibres according to claim 1 , comprising the steps of:
a) Providing said at least one lipid in a solvent; b) Optionally adding at least one surfactant, at least one excipient and optionally at least one mucoadhesive compound and optionally at least one porogen compound; c) Dispersing at least one active ingredient in the mixture obtained in step b; and d) Applying an electrical field to obtain a composite nano-micro-structure.

15 . (canceled)

16 . A method of oromucosal delivery of at least one active ingredient, said method comprising administering to a subject a composition of claim 1 .

17 . The composition according to claim 2 , wherein said lipid nano-micro-structure is selected from the group comprising solid lipid nano-microparticles and solid lipid nano-microfibres.

18 . The composition of claim 3 , wherein said nicotine component is nicotine bitartrate.

19 . The composition of claim 4 , wherein said flavour component is selected from the group consisting of vanillin, R-carvone, limonene, eugenol, eucalyptol, cinnamaldehyde, thymol, anisole, and citral.

20 . The composition according to claim 6 , wherein said at least one lipid is selected from the group consisting of capric, lauric, myristic, palmitic, stearic, and arachidic acids and mono-, di- and triglycerides thereof.

21 . The composition of claim 20 , wherein said at least one lipid is selected from the group consisting of trimyristin, tripalmitin, tristearin, tricaprin, myristic acid, palmitic acid, stearic acid, and behenic acid.

Assignees

• Univ Danmarks Tekniske

Inventors

• Chronakis Ioannis S
• Jorgensen Lars
• Mattebjerg Maria Ahlm

Classifications

• A23G4/06

  characterised by the composition {containing organic or inorganic compounds} · CPC title

• A23G4/00

  Chewing gum · CPC title

• A61K9/5123

  Organic compounds, e.g. fats, sugars · CPC title

• A61K9/006

  Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays · CPC title

• A61K9/5176

  Compounds of unknown constitution, e.g. material from plants or animals (oils, fats, waxes, shellac A61K9/5123) · CPC title