Microscope for High Spatial Resolution Imaging a Structure of Interest in a Sample
US-2015076333-A1 · Mar 19, 2015 · US
US2016015264A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2016015264-A1 |
| Application number | US-201514802160-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jul 17, 2015 |
| Priority date | Jul 17, 2014 |
| Publication date | Jan 21, 2016 |
| Grant date | — |
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An imaging system and method for using an optical device with an electronic device for diagnostic imaging is provided. The imaging system may include a controller configured to capture a series of holograms by powering a light source of the optical device to illuminate an object, wherein light from the light source is collimated onto the object through an aperture of the optical device. The controller may be configured to extract an interference pattern of the object from the series of holograms, wherein the interference pattern is produced by interference between a reflected beam from the object and a reference beam formed by a diffraction mirror of the optical device. The controller may be configured to record at least one image of the object based on the interference pattern. The imaging system may include a data storage configured to store the at least one image.
Opening claim text (preview).
What is claimed is: 1 . An imaging system for using an optical device with an electronic device for diagnostic imaging, wherein the imaging system comprises: a controller configured to capture a series of holograms by powering a light source of the optical device to illuminate an object, wherein light from the light source is collimated onto the object through an aperture of the optical device, extract an interference pattern of the object from the series of holograms, wherein the interference pattern is produced by interference between a reflected beam from the object and a reference beam formed by a diffraction mirror of the optical device, and record at least one image of the object based on the interference pattern; and a non-transitory data storage configured to store the at least one image. 2 . The imaging system of claim 1 , wherein, when recording the at least one image of the object based on the interference pattern, the imaging system is configured to: obtain a frequency spectrum of the object by obtaining a Fresnel transform of an amplitude and a phase retrieved from the interference pattern, wherein a high frequency portion in the frequency spectrum is recovered using an iterative restoration approach; and obtain the at least one image of the object by obtaining a Fourier transform of the frequency spectrum, wherein the at least one image is a low-resolution image. 3 . The imaging system of claim 1 , wherein, when recording the at least one image of the image based on the interference pattern, the imaging system is configured to: obtain a frequency spectrum of the object by obtaining a Fresnel transform of an amplitude and a phase retrieved from the interference pattern, wherein a high frequency portion in the frequency spectrum is recovered using an iterative restoration approach; and obtain the at least one image of the object by obtaining an inverse Fourier transform of the frequency spectrum, wherein the at least one image is a high-resolution image. 4 . The imaging system of claim 1 , wherein the light is partially reflected and partially transmitted by a beam splitter. 5 . The imaging system of claim 4 , wherein the light is split by the beam splitter into an incident beam and the reference beam, and the incident beam passes through a phase plate and is reflected from the object. 6 . The imaging system of claim 1 , wherein the reference beam is formed by the light source. 7 . The imaging system of claim 1 , wherein the optical device comprises an adaptor, the adaptor comprising: a housing facility comprising a proximal end and a distal end, the housing facility being configured to removably attach to the electronic device at the proximal end, and the proximal end is configured to surround an imaging sensor of the electronic device and the distal end is configured to be fixed on or near the object using a head strap. 8 . The imaging system of claim 1 , wherein the imaging system is further configured to: display the recorded at least one image on the electronic device; and authenticate the recorded at least one image by comparing the recorded at least one image to at least one pre-stored image of the object. 9 . A method of operating an optical device, the method comprising: capturing a series of holograms by powering a light source associated with the optical device to illuminate an object, wherein light from the light source is collimated onto the object through an aperture; extracting an interference pattern of the object from the series of holograms, wherein the interference pattern is produced by interference between a reflected beam from the object and a reference beam formed by a diffraction mirror associated with the optical device; recording at least one image of the object based on the interference pattern; and storing the at least one image in a data storage of an electronic device. 10 . The method of claim 9 , wherein the recording of the at least one image comprises: obtaining a frequency spectrum of the object by obtaining a Fresnel transform of an amplitude and a phase retrieved from the interference pattern, wherein a high frequency portion in the frequency spectrum is recovered using an iterative restoration approach; and obtaining the at least one image of the object by obtaining a Fourier transform of the frequency spectrum, wherein the at least one image is a low-resolution image. 11 . The method of claim 9 , wherein the recording of the at least one image comprises: obtaining a frequency spectrum of the object by obtaining a Fresnel transform of an amplitude and a phase retrieved from the interference pattern, wherein a high frequency portion in the frequency spectrum is recovered using an iterative restoration approach; and obtaining the at least one image of the object by obtaining an inverse Fourier transform of the frequency spectrum, wherein the at least one image is a high-resolution image. 12 . The method of claim 9 , wherein the light is partially reflected and partially transmitted by a beam splitter. 13 . The method of claim 12 , wherein the light is split by the beam splitter into an incident beam and the reference beam, and the incident beam passes through a phase plate and is reflected from the object. 14 . The method of claim 9 , wherein the reference beam is formed by the light source. 15 . The method of claim 9 , further comprising: displaying the recorded at least one image on the electronic device; and authenticating the recorded at least one image by comparing the recorded at least one image to at least one pre-stored image of the object. 16 . An imaging system for recording at least one image of an object, the imaging system comprising: a housing facility comprising a light source, an aperture, a diffraction mirror, a head strap, a display screen, a data storage, and a controller, wherein: the housing facility comprises a proximal end and a distal end, and is configured to attach to the display screen at the proximal end; and the controller is configured to capture a series of holograms by powering the light source to illuminate the object, wherein light from the light source is collimated onto the object through the aperture, extract an interference pattern of the object from the series of holograms, wherein the interference pattern is produced by interference between a reflected beam from the object and a reference beam formed by the diffraction mirror, record at least one image of the object based on the interference pattern, and store the at least one image in the data storage. 17 . The imaging system of claim 16 , wherein, when recording the at least one image of the object based on the interference pattern, the controller is further configured to: obtain a frequency spectrum of the object by obtaining a Fresnel transform of an amplitude and a phase retrieved from the interference pattern, wherein a high frequency portion in the frequency spectrum is recovered using an iterative restoration approach; and obtain the at least one image of the object by obtaining a Fourier transform of the frequency spectrum, wherein the at least one image is a low-resolution image. 18 . The imaging system of claim 16 , wherein, when recording the at least one image of the object based on the interference pattern, the controller is further configured to: obtain a frequency spectrum of the object by obtaining a Fresnel transform of an amplitude and a phase retrieved from the interference pattern, wherein a high frequency portion in
Arrangements specially adapted for eye photography · CPC title
characterised by electronic signal processing, e.g. eye models · CPC title
Methods of numerical synthesis, e.g. coherent ray tracing [CRT], diffraction specific · CPC title
using Fourier transform ({G03H1/10}, G03H1/12, G03H1/14 take precedence; analogue computers G06G, e.g. G06G7/19) · CPC title
Eye; Retina; Ophthalmic · CPC title
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