Apoptosis-inducing agent for the treatment of cancer and immune and autoimmune diseases

Patent metadata

Field	Value
Publication number	US-2016002187-A1
Application number	US-201514855176-A
Country	US
Kind code	A1
Filing date	Sep 15, 2015
Priority date	Jan 19, 2009
Publication date	Jan 7, 2016
Grant date	—

Abstract

Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.

First claim

1 - 4 . (canceled)

5 . A compound, or therapeutically acceptable salt thereof, wherein the compound is selected from the group consisting of:
N-{[2-(acetylamino)-4-methyl-1,3-thiazol-5-yl]sulfonyl)}-4-{4-[(4′-chloro-1,1′-biphenyl-2-yl)methyl]piperazin-1-yl}benzamide; and 4-{4-[(4′-chloro-1,1′-biphenyl-2-yl)methyl]piperazin-1-yl}-N-[(2,4-dimethyl-1,3-thiazol-5-yl)sulfonyl]benzamide.

6 . A composition comprising an excipient and a therapeutically effective amount of the compound or therapeutically acceptable salt of claim 5 .

7 - 8 . (canceled)

Assignees

• Abbvie Inc

Inventors

• Kunzer Aaron R
• Elmore Steven W
• Hexamer Laura A
• Park Cheol-Min
• Souers Andrew J
• Sullivan Gerard M
• Wang Gary T
• Wang Xilu
• Wendt Michael D

Classifications

• C07D295/155

  with the ring nitrogen atoms and the carbon atoms with three bonds to hetero atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings · CPC title

• C07D285/125

  with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical · CPC title

• C07D333/42

  with nitro or nitroso radicals directly attached to ring carbon atoms · CPC title

• C07D409/12

  linked by a chain containing hetero atoms as chain links · CPC title

• C07D277/36

  Sulfur atoms · CPC title