Systems and methods for spectrally dispersed illumination optical coherence tomography

Patent metadata

Field	Value
Publication number	US-2016000320-A1
Application number	US-201514789889-A
Country	US
Kind code	A1
Filing date	Jul 1, 2015
Priority date	Jul 3, 2014
Publication date	Jan 7, 2016
Grant date	—

Abstract

Systems and methods are presented for acquisition and processing of spectrally dispersed illumination optical coherence tomographic data. Light from a source is distributed spectrally on the sample, and each acquisition simultaneously provides partial spectral interference information from multiple locations in the sample. Thus for a given spatial point, a single observation will be of a partial spectrum A-scan. When multiple partial spectrum A-scan observations are made at the same point by shifting the spectrum of light on to the tissue, the point can be observed by the entire broadband spectrum of the light source, thereby making it possible to create a full axial resolution A-scan.

First claim

1 . An optical coherence tomographic system to image a sample, comprising:
a light source for generating a beam of light, which is divided into a reference arm light and a sample arm light; an optical train in the sample arm containing a spectral disperser for dispersing the beam-of-light into a spectrum and laterally translating the spectrum along said sample in a direction parallel to the spread of the spectrum such that spatial points of said sample can be illuminated by at least two distinct portions of said spectrum by the translation of said spectrum with respect to the sample; an interferometer including a detector, for interfering back-reflected light from said spatial points with reference arm light to yield two or more partial spectrum A-scans; and a processor, for combining the two or more partial spectrum A-scans each obtained with distinct portions of said spectrum at a given spatial point into a combined A-scan.

2 . A system as recited in claim 1 wherein the spectral disperser can be rotated.

3 . A system as recited in claim 1 in which the spectral disperser is selected from the group consisting of dispersing transmission prism, dispersing reflection prism, reflection grating, transmission grating, grism, spectrally dispersing fiber or fibers, and multiband wavelength demultiplexer.

4 . A system as recited in claim 1 wherein said processor converts one or more combined A-scans into an image.

5 . A system as recited in claim 1 wherein the light returning from the sample is spectrally combined by the spectral disperser and delivered to an optical fiber wherein the output of the optical fiber is directed to the detector.

6 . A system as recited in claim 1 wherein the detector is a spectrometer including optics to angularly disperse the beam as function of wavelength to fall on a linear array of detector elements with the position of the detector elements within the array being mapped to the illuminated spatial points on the sample.

7 . A system as recited in claim 1 wherein the wavelength of the light generated by the light source is swept in time.

8 . A system as recited in claim 7 wherein the detector is a photodetector with the detection time being mapped to the illuminated spatial points on the sample.

9 . A method to image a patient's eye with an OCT instrument, comprising:
dispersing a beam-of-light as a function of wavelength onto a sample to illuminate a set of spatial points, wherein each spatial point along the direction of dispersion is illuminated by a different wavelength component of the beam; interfering back-reflected light from the sample with a reference beam and detecting a partial spectrum A-scan at each spatial point; moving the spectrally dispersed beam of light along the direction of dispersion and obtaining multiple partial spectrum A-scans at each spatial point; processing the partial spectrum A-scans associated with individual spatial points to generate combined A-scans; and, displaying, storing, or further processing said combined A-scans.

10 . A method as recited in claim 9 wherein the light back reflected from the eye is spectrally recombined and delivered to an optical fiber wherein the output of the optical fiber is directed a detector.

11 . A method as recited in claim 10 wherein the detector is a spectrometer including optics to angularly disperse the beam as function of wavelength to fall on a linear array of detector elements with the position of the detector elements within the array being mapped to the location of particular wavelengths of radiation on the eye.

12 . A method as recited in claim 9 wherein the beam of light is dispersed by an optical element selected from the group consisting of dispersing transmission prism, dispersing reflection prism, reflection grating, transmission grating, grism, spectrally dispersing fiber or fibers, and multiband wavelength demultiplexer.

13 . A system as recited in claim 12 wherein the optical element is rotated.

14 . A method as recited claim 9 wherein the beam of light is generated by a light source and wherein the wavelength of the light generated by the light source is swept in time.

15 . An optical coherence tomography system comprising:
a light source for generating a beam of radiation; a beam splitter for dividing the beam between a sample path and a reference path; optics, located in the sample path, for angularly dispersing the beam as a function of wavelength to create an elongated beam spot that varies in wavelength over the length of the spot, said spot being directed to illuminate the sample; collection optics to combine and interfere radiation returning from the sample and from the reference path; a spectrometer including optics to angularly disperse the beam as function of wavelength to fall on a linear array of detector elements with the position of the detector elements within the array being mapped to the location of particular wavelengths of radiation on the sample; and a scanner for scanning the elongated beam spot along the length axis of the beam to sequentially change the wavelength of light falling on each illuminated location on the sample wherein the multiple wavelength information collected from each illuminated location on the sample corresponds to the reflected intensity as a function of depth in the sample at that location.

16 . A system as recited in claim 15 wherein the light returning from the sample is spectrally combined by the dispersing optics and delivered to an optical fiber wherein the output of the optical fiber is directed to the spectrometer.

17 . A system as recited in claim 15 wherein the dispersing optics is selected from the group consisting of dispersing transmission prism, dispersing reflection prism, reflection grating, transmission grating, grism, spectrally dispersing fiber or fibers, and multiband wavelength demultiplexer.

18 . A system as recited in claim 17 wherein the dispersing optics are rotated.

19 . An optical coherence tomography system comprising:
a light source for generating a beam of radiation, wherein the wavelength of the light is swept is in time; a beam splitter for dividing the beam between a sample path and a reference path; optics, located in the sample path, for angularly directing the beam as a function of wavelength so that the beam is scanned over a linear array of locations on the sample as the wavelength of the light is swept; collection optics to combine and interfere radiation returning from the sample and from the reference path; a detector for measuring the intensity of the interfered radiation, with the detection time being mapped to the location of particular wavelengths of radiation on the sample; and a scanner for scanning the beam in a direction parallel to the linear array of locations on the sample to sequentially change the wavelength of light falling on each illuminated location on the sample wherein the multiple wavelength information collected from each illuminated location on the sample corresponds to the reflected intensity as a function of depth in the sample at that location.

Assignees

• Zeiss Carl Meditec Inc

Inventors

• Sharma Utkarsh
• Schmoll Tilman
• Wei Xing

Classifications

• G01J3/2823

  Imaging spectrometer · CPC title

• A61B3/102 Primary

  for optical coherence tomography [OCT] · CPC title

• A61B3/0025

  characterised by electronic signal processing, e.g. eye models · CPC title

• G01J3/45

  Interferometric spectrometry · CPC title

• A61B3/14

  Arrangements specially adapted for eye photography · CPC title