Adjustable chromophore compounds and materials incorporating such compounds

Patent metadata

Field	Value
Publication number	US-2015306562-A1
Application number	US-201514792877-A
Country	US
Kind code	A1
Filing date	Jul 7, 2015
Priority date	Apr 2, 2010
Publication date	Oct 29, 2015
Grant date	—

Abstract

The present invention is directed to adjustable chromophore compounds and materials (e.g., ophthalmic lens materials) incorporating those compounds. The adjustable chromophore compounds include a chemical moiety that structurally changes upon exposure to predetermined electromagnetic radiation (e.g., two photon radiation) as well as lens materials, particularly intraocular lens materials that incorporate those compounds.

First claim

1 - 21 . (canceled)

22 . A method of adjusting a lens, the method comprising:
providing a lens having a compound of the formula:
B—X;

wherein: i) B is a base chromophore compound; and ii) X is an adjustable chemical moiety; exposing the compound B—X to predetermined electromagnetic radiation thereby forming the compound:
B—C;

wherein: i) the compound B—C provided greater light absorption than the compound B—X; and ii) the remaining chemical moiety (C) includes a conjugated double bond.

23 . A method as in claim 22 wherein the base chromophore compound is selected from the group consisting of benzotriazoles, benzophenones, azo dyes and cinnamate esters.

24 . A method as in claim 23 wherein the base chromophore compound is a benzotriazole.

25 . A method as in claim 23 wherein the compound B—C absorbs a significant amount of UV light, blue light or both.

26 . A method as in claim 25 wherein the compound B—C absorbs a significant amount of blue light.

27 . A method as in claim 23 wherein the adjustable chemical moiety X is a cyclic moiety.

28 . A method as in claim 23 wherein the adjustable chemical moiety X is dicyclopentadiene.

29 . A method as in claim 22 wherein:
i) the lens is formed of a polymeric material;
ii) the adjustable chromophore compound is distributed within the polymeric material; and
iii) the polymeric material can absorb light at progressively greater wavelengths as greater amounts of the compound B—C are formed from the adjustable compound B—X.

30 . A method as in claim 29 further comprising:
implanting the lens within an eye of an individual wherein the step of exposing the compound B—X to the predetermined electromagnetic radiation to form the compound B—C occurs after implanting of the lens in the eye.

31 . A method of adjusting a lens, the method comprising:
providing a lens having a compound of the formula:
B—X or B—C

as part of the reactive system:
B—X⇄B—C

wherein: i) B is a base chromophore compound; ii) X is an adjustable chemical moiety that forms remaining chemical moiety (C) upon exposure to first predetermined electromagnetic radiation thereby forming the compound B—C; iii) the compound B—C provides greater light absorption than the compound B—X; and iv) the remaining chemical moiety (C) includes a conjugated double bond; and v) the compound B—C forms the compound B—X upon exposure to second predetermined electromagnetic radiation either with or without the aid of a separable group (S)and exposing either: i) the compound B—X to the first predetermined electromagnetic radiation to form the compound B—C; or ii) the compound B—C to the second predetermined electromagnetic radiation to form the compound B—X.

32 . A method as in claim 31 wherein the base chromophore compound is selected from the group consisting of benzotriazoles, benzophenones, azo dyes and cinnamate esters.

33 . A method as in claim 32 wherein the base chromophore compound is a benzotriazole.

34 . A method as in claim 31 wherein the compound B—C absorbs a significant amount of blue light.

35 . A method as in claim 32 wherein the adjustable chemical moiety X is a cyclic moiety.

36 . A method as in claim 35 wherein the adjustable chemical moiety X is dicyclopentadiene.

Assignees

• Novartis Ag

Inventors

• Weinschenk Iii Joseph I

Classifications

• B01J19/127

  Sunlight; Visible light · CPC title

• G02B1/043

  Contact lenses · CPC title

• C07D249/20

  with aryl radicals directly attached in position 2 · CPC title

• C08K5/3475

  condensed with carbocyclic rings · CPC title

• A61L2430/16

  for reconstruction of eye parts, e.g. intraocular lens, cornea · CPC title