Methods and nucleic acid molecules for aav vector selection
US-2024417717-A1 · Dec 19, 2024 · US
US2015225741A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2015225741-A1 |
| Application number | US-201414298553-A |
| Country | US |
| Kind code | A1 |
| Filing date | Jun 6, 2014 |
| Priority date | May 20, 2008 |
| Publication date | Aug 13, 2015 |
| Grant date | — |
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Provided herein are compositions and methods for gene and etiology-nonspecific and circuit-specific treatment of diseases, utilizing vectors for delivery of light-sensitive proteins to diseased and normal cells and tissues of interest.
Opening claim text (preview).
What is claimed is: 1 . A recombinant nucleic acid comprising a nucleic acid encoding a light-sensitive protein operatively linked to a metabotropic glutamate receptor 6 (mGluR6) regulatory sequence or fragment thereof. 2 . The nucleic acid of claim 1 wherein the light-sensitive protein is selected from the group consisting of ChR1, ChR2, VChR1, ChR2 C128A, ChR2 C128S, ChR2 C128T, ChR1-ChR2 hybrids/chimeras, ChD, ChEF, ChF, ChIEF, NpHR, eNpHR, melanopsin,…
Human Necessities · mapped topic
Human Necessities · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
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