Compositions and methods for viral sensitization
US-2024360115-A1 · Oct 31, 2024 · US
US2015094271A1 · US · A1
| Field | Value |
|---|---|
| Publication number | US-2015094271-A1 |
| Application number | US-201414502088-A |
| Country | US |
| Kind code | A1 |
| Filing date | Sep 30, 2014 |
| Priority date | Sep 30, 2013 |
| Publication date | Apr 2, 2015 |
| Grant date | — |
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A leucine zipper variant, a polynucleotide encoding the leucine zipper variant, a method of preparing a leucine zipper variant, a method of inhibiting HDM2- and/or HDMX using the leucine zipper variant, and a method of the prevention and/or treatment of cancer using the leucine zipper variant.
Opening claim text (preview).
What is claimed is: 1 . A leucine zipper polypeptide variant comprising SEQ ID NO: 1 with an amino acid substitution at one or more of positions 10, 14, 15, 18 and 21. 2 . The leucine zipper polypeptide variant of claim 1 , wherein the substitution is selected from the group consisting of: (a) substitution of glutamic acid (E) with glycine (G) at position 10; (b) substitution of lysine (K) with serine (S) at position 15; (c substitution of serine (S) w…
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