Determination and application of glucose sensor reliability indicator and/or metric

Patent metadata

Field	Value
Publication number	US-2015073244-A1
Application number	US-201414539855-A
Country	US
Kind code	A1
Filing date	Nov 12, 2014
Priority date	Oct 28, 2010
Publication date	Mar 12, 2015
Grant date	—

Abstract

Disclosed are a system and method for determining a metric and/or indicator of a reliability of a blood glucose sensor in providing glucose measurements. In one aspect, the metric and/or indicator may be computed based, at least in part, on an observed trend associated with signals generated by the blood glucose sensor.

First claim

What is claimed is:

1 . A method comprising:
determining an indicator of reliability of a blood glucose sensor, the blood glucose sensor comprising two or more pairs of sensor elements, said indicator of reliability of said blood glucose sensor being based, at least in part, on an observed correlation of output signals generated by at least a first pair of said pairs of sensor elements; and generating a signal to suggest replacement of said blood glucose sensor based, at least in part, on said indicator of reliability of said blood glucose sensor.

2 . The method of claim 1 , wherein said indicator of reliability of said blood glucose sensor is further based, at least in part, on an additional observed correlation of output signals generated by at least a second pair of said pairs of sensor elements.

3 . The method of claim 1 , and further comprising displaying an image on a display based, at least in part, on said indicator of reliability.

4 . The method of claim 1 , wherein said blood glucose sensor is coupled to an insulin pump as part of a system to provide closed-loop continuous insulin infusion to a patient, the method further comprising transitioning said system from closed loop operation to an open loop or manual operation based, at least in part, on said indicator of reliability.

5 . The method of claim 1 , and further comprising displaying an indicator requesting additional or more frequent metered blood glucose reference samples for calibration of said blood glucose sensor in response to said indicator of reliability to thereby extend an operating life of said blood glucose sensor.

6 . The method of claim 1 , wherein said indicator of reliability is further based, at least in part, on an observed trend in output signals generated by said blood glucose sensor.

7 . The method of claim 6 , wherein said observed trend comprises detection of a reduced sensitivity of said blood glucose sensor in responding to a presence of glucose.

8 . The method of claim 6 , wherein said observed trend comprises further comprises one or more detected non-physiological anomalies.

9 . The method of claim 6 , wherein said observed trend comprises a sensor drift.

10 . The method of claim 6 , wherein said observed trend comprises a noise trend.

11 . The method of claim 1 , wherein said indicator of reliability further based, at least in part, on an indicator of a reliability of a calibration of said blood glucose sensor.

12 . An apparatus comprising:
a blood glucose sensor to generate signals responsive to a concentration of glucose in a fluid, said blood glucose sensor comprising two or more pairs of sensor elements; one or more processors to:
determine an indicator of reliability of said blood glucose sensor, said indicator of reliability of said blood glucose sensor being based, at least in part, on an observed correlation of output signals generated by at least a first pair of said pairs of sensor elements; and
generate a signal to suggest replacement of said blood glucose sensor based, at least in part, on said indicator of reliability of said blood glucose sensor.

13 . The apparatus of claim 12 , wherein said indicator of reliability of said blood glucose sensor is further based, at least in part, on an additional observed correlation of output signals generated by at least a second pair of said pairs of sensor elements.

14 . The apparatus of claim 12 , and further comprising a display device, wherein said one or more processors are further to initiate an image on the display device based, at least in part, on said indicator of reliability.

15 . The apparatus of claim 12 , and further comprising an insulin pump coupled to said blood glucose sensor as part of a system to provide closed-loop continuous insulin infusion to a patient, wherein said one or more processors are further to initiate transition of said system from closed loop operation to an open loop or manual operation based, at least in part, on said indicator of reliability.

16 . The apparatus of claim 12 , and further comprising a display device, wherein said one or more processors are further to initiate an image on said display device, the image requesting additional or more frequent metered blood glucose reference samples for calibration of said blood glucose sensor in response to said indicator of reliability to thereby extend an operating life of said blood glucose sensor.

17 . The apparatus of claim 12 , wherein said indicator of reliability is further based, at least in part, on an observed trend in said output signals generated by said blood glucose sensor.

18 . An article comprising:
a non-transitory storage medium comprising machine-readable instructions stored thereon which are executable by a special purpose computing apparatus to:
determine an indicator of reliability of a blood glucose sensor, the blood glucose sensor comprising two or more pairs of sensor elements, said indicator of reliability of said blood glucose sensor being based, at least in part, on an observed correlation of output signals generated by at least a first pair of said pairs of sensor elements; and
generate a signal to suggest replacement of said blood glucose sensor based, at least in part, on said indicator of reliability of said blood glucose sensor.

19 . The article of claim 18 , wherein said indicator of reliability of said blood glucose sensor is further based, at least in part, on an additional observed correlation of output signals generated by at least a second pair of said pairs of sensor elements.

20 . The article of claim 18 , wherein said instructions are further executable by said special purpose computing apparatus to initiate an image on a display device based, at least in part, on said indicator of reliability.

21 . The article of claim 18 , wherein said instructions are further executable by said special purpose computing apparatus to initiate transition of a system from closed loop operation to an open loop or manual operation based, at least in part, on said indicator of reliability, said system comprising an insulin pump coupled to said blood glucose sensor.

22 . The article of claim 18 , wherein said instructions are further executable by said special purpose computing apparatus to initiate an image on a display device, the image requesting additional or more frequent metered blood glucose reference samples for calibration of said blood glucose sensor in response to said indicator of reliability to thereby extend an operating life of said blood glucose sensor.

23 . The article of claim 18 , wherein said indicator of reliability is further based, at least in part, on an observed trend in output signals generated by said blood glucose sensor.

Assignees

• Medtronic Minimed Inc

Inventors

• Gottlieb Rebecca K
• Luo Ying
• Gautham Raghavendhar
• Liang Bradley
• Roy Anirban
• Cooper Kenneth W
• Shah Rajiv
• Keenan Barry

Classifications

• A61B5/6849

  in combination with a needle set · CPC title

• A61B5/1495

  Calibrating or testing of in-vivo probes · CPC title

• A61M2205/3303

  Using a biosensor · CPC title

• A61M2005/1726

  the body parameters being measured at, or proximate to, the infusion site · CPC title

• A61B5/1473

  invasive, e.g. introduced into the body by a catheter · CPC title