Vagal nerve stimulation devices and methods

Patent metadata

Field	Value
Publication number	US-12598433-B2
Application number	US-202519260226-A
Country	US
Kind code	B2
Filing date	Jul 3, 2025
Priority date	Aug 19, 2010
Publication date	Apr 7, 2026
Grant date	Apr 7, 2026

Abstract

Vagal nerve stimulation devices and methods are provided herein. A device comprises one or more electrodes having a contact surface for contacting an outer skin surface of a patient and an energy source coupled to the electrodes. The energy source generates one or more electrical impulses and transmits the electrical impulses to the electrodes and transcutaneously through the outer skin surface of the patient at or near a vagus nerve. The one or more electrical pulses comprise bursts of 2 to 20 pulses within each burst with each burst having a frequency of about 5 Hz to about 100 Hz.

First claim

The invention claimed is:

1 . A device comprising:
one or more electrodes; and a power source coupled to the electrodes, wherein the power source is configured to generate one or more electrical impulses and to transmit the electrical impulses to the electrodes through an outer skin surface of a user at or near a vagus nerve, wherein each of the one or more electrical impulses comprises bursts, wherein each burst comprises a burst period having 2 to 20 pulses and a constant period having zero pulses and wherein each burst has a frequency of about 5 Hz to about 100 Hz.

2 . The device of claim 1 further comprising a housing, wherein the power source is housed within the housing and the electrodes are coupled to the housing.

3 . The device of claim 2 , wherein the one or more electrodes are housed within, or incorporated into, the housing.

4 . The device of claim 1 , wherein the one or more electrical impulses is sufficient to modulate activity of the vagus nerve to release one or more inhibitory neurotransmitters within a brain of the user.

5 . The device of claim 1 , further comprising a signal generator coupled to the power source.

6 . The device of claim 5 , wherein the signal generator generates zero pulses during the constant periods.

7 . The device of claim 1 , wherein each burst has a frequency from about 15 Hz to about 50 Hz, and, wherein the pulses alternate between a positive voltage and a negative voltage within each of the burst periods.

8 . The device of claim 1 , wherein each pulse within each burst period has a duration of about 20 to about 1000 microseconds.

9 . The device of claim 1 , wherein the outer skin surface is a neck of the user.

10 . The device of claim 1 , wherein the outer skin surface is in or around the ear of the user.

11 . The device of claim 1 , wherein the one or more electrical impulses are sufficient to relieve a symptom of anxiety or stress.

12 . A method comprising:
positioning one or more electrodes in contact with an outer skin surface of a user; generating one or more electrical impulses; and transmitting the one or more electrical impulses to the one or more electrodes through the outer skin surface of the user at or near a vagus nerve within the user, wherein each of the one or more electrical impulses comprises-bursts, wherein each burst comprises a burst period having 2 to 20 pulses and a constant period having zero pulses and wherein each burst has a frequency of about 5 Hz to about 100 Hz.

13 . The method of claim 12 , wherein the one or more electrical impulses are generated within a housing and transmitted to the one or more electrodes within the housing.

14 . The method of claim 12 , wherein the one or more electrical impulses is sufficient to modulate activity of the vagus nerve to release one or more inhibitory neurotransmitters within a brain of the user.

15 . The method of claim 12 , wherein the one or more electrical impulses is generated by a signal generator.

16 . The method of claim 12 , wherein each burst has a frequency from about 15 Hz to about 50 Hz, and, wherein the pulses alternate between a positive voltage and a negative voltage within each of the burst periods.

17 . The method of claim 12 , wherein each pulse within each burst period has a duration of about 20 to about 1000 microseconds.

18 . The method of claim 12 , wherein the outer skin surface is a neck of the user.

19 . The method of claim 12 , wherein the outer skin surface is in or around the ear of the user.

20 . The method of claim 12 , wherein the one or more electrical impulses are sufficient to relieve a symptom of anxiety or stress.

Assignees

• Electrocore Inc

Inventors

• Simon Bruce J
• Errico Joseph P
• Raffle John T

Classifications

• A61N1/36053

  adapted for vagal stimulation (A61N1/36114 takes precedence) · CPC title

• A61N1/36014 Primary

  External stimulators, e.g. with patch electrodes (external pacemakers A61N1/3625) · CPC title

• A61N1/36034

  specified by the stimulation parameters · CPC title

• A61N2/02

  using magnetic fields produced by coils, including single turn loops or electromagnets (A61N2/12 takes precedence) · CPC title

• A61N2/008

  for pain treatment or analgesia · CPC title