Lipid Abnormalities and Association with Atopic Allergic Diseases
US-2024159778-A1 · May 16, 2024 · US
Prediction of the content of omega-3 polyunsaturated fatty acids in the retina by measuring 7 cholesterol ester molecules
US12596127B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12596127-B2 |
| Application number | US-202017762928-A |
| Country | US |
| Kind code | B2 |
| Filing date | Sep 24, 2020 |
| Priority date | Sep 24, 2019 |
| Publication date | Apr 7, 2026 |
| Grant date | Apr 7, 2026 |
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Abstract
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The present invention relates to a method for determining the content of omega-3 polyunsaturated fatty acids in the retina of a subject comprising the determination of the content of at least one cholesteryl ester in a blood sample from said subject, the content of omega-3 polyunsaturated fatty acids in the retina being correlated to the content of said at least one cholesteryl ester, said at least one cholesteryl ester being cholesteryl 5,8,11,14,17-eicosapentaenoate.
First claim
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The invention claimed is: 1 . A method for determining the content of omega-3 polyunsaturated fatty acids in the retina of a subject comprising determining the content of at least one cholesteryl ester in a blood sample from said subject, the content of omega-3 polyunsaturated fatty acids in the retina being correlated to the content of said at least one cholesteryl ester, said at least one cholesteryl ester being cholesteryl 5,8,11,14,17-eicosapentaenoate. 2 . The method as claimed in claim 1 , wherein the blood sample is chosen from whole blood, serum and plasma. 3 . The method as claimed in claim 1 , wherein the determining step includes isolating plasma from the blood sample; extracting total lipids from the plasma; isolating the at least one cholesteryl ester from the total lipids; forming methyl esters of fatty acids resulting from hydrolysis of the at least one cholesteryl ester; determining a relative amount of the methyl esters; and calculating an estimated value of the content of omega-3 polyunsaturated fatty acids in the retina from the relative amount of fatty acid methyl esters of the at least one cholesteryl ester. 4 . The method as claimed in claim 1 , wherein the content of seven cholesteryl esters is determined. 5 . The method as claimed in claim 4 , wherein the seven cholesteryl esters are cholesteryl 5,8,11,14,17-eicosapentaenoate, cholesteryl 9,12,15-octadecatrienoate, cholesteryl 4,7,10,13,16,19-docosahexaenoate, cholesteryl 9,12-octadecadienoate, cholesteryl 6,9,12-octadecatrienoate, cholesteryl 8,11,14-eicosatrienoate, cholesteryl 5,8,11,14-eicosatetraenoate.
Assignees
- Univ De Bordeaux
- Inserm Institut National De La Sante Et De La Rech Medicale
- Institut National De Rech Pour Lagriculture Lalimentation Et Lenvironnement
- Univ De Bourgogne
- Institut Nat Superieur Des Sciences Agronomiques De Lalimentation Et De Lenvironnement
- Institut Nat Superieur Des Sciences Agronomiques De Lalimentation Et De Levironnement
Inventors
Classifications
Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis · CPC title
Retinal disorders, e.g. retinopathy · CPC title
- G01N33/92Primary
involving lipids, e.g. cholesterol {, lipoproteins, or their receptors (steroid hormones G01N33/743)} · CPC title
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- What does patent US12596127B2 cover?
- The present invention relates to a method for determining the content of omega-3 polyunsaturated fatty acids in the retina of a subject comprising the determination of the content of at least one cholesteryl ester in a blood sample from said subject, the content of omega-3 polyunsaturated fatty acids in the retina being correlated to the content of said at least one cholesteryl ester, said at l…
- Who is the assignee on this patent?
- Univ De Bordeaux, Inserm Institut National De La Sante Et De La Rech Medicale, Institut National De Rech Pour Lagriculture Lalimentation Et Lenvironnement, and 3 more
- What technology area does this patent fall under?
- Primary CPC classification G01N33/92. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Apr 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).