Genetically Modified Yeast Species, and Fermentation Processes Using Genetically Modified Yeast
US-2016340697-A1 · Nov 24, 2016 · US
Microorganism of Corynebacterium genus having enhanced L-arginine or L-citrulline productivity and a method for producing L-arginine or L-citrulline using the same
US12595461B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12595461-B2 |
| Application number | US-202217937828-A |
| Country | US |
| Kind code | B2 |
| Filing date | Oct 4, 2022 |
| Priority date | Jul 21, 2022 |
| Publication date | Apr 7, 2026 |
| Grant date | Apr 7, 2026 |
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- Title
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Abstract
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The present disclosure relates to a Corynebacterium sp. mutant strain having increased L-arginine or L-citrulline productivity and a method of producing L-arginine or L-citrulline using the same. The Corynebacterium sp. mutant strain has enhanced activity of acetylglutamate kinase involved in the L-arginine biosynthesis pathway, and thus is capable of producing L-arginine or L-citrulline in an increased yield compared to a parent strain.
First claim
Opening claim text (preview).
What is claimed is: 1 . A Corynebacterium sp. mutant strain having increased L-arginine or L-citrulline productivity by having enhanced activity of acetylglutamate kinase, wherein said acetylglutamate kinase of the Corynebacterium sp. mutant strain having increased L-citrulline productivity has a substitution of aspartic acid for histidine at amino acid position 245 in the amino acid sequence of SEQ ID NO: 2, wherein said acetylglutamate kinase of the Corynebacterium sp. mutant strain having increased L-arginine productivity has a substitution of leucine for glutamic acid at amino acid position 258 or a substitution of aspartic acid for histidine at amino acid position 245 in the amino acid sequence of SEQ ID NO: 2. 2 . The Corynebacterium sp. mutant strain of claim 1 , which is Corynebacterium glutamicum. 3 . A method for producing L-arginine or L-citrulline comprising steps of: culturing the Corynebacterium sp. mutant strain of claim 1 in a medium; and recovering L-arginine or L-citrulline from the cultured mutant strain or the medium in which the mutant strain has been cultured.
Assignees
Inventors
Classifications
Corynebacterium · CPC title
Acetylglutamate kinase (2.7.2.8) · CPC title
Citrulline; Arginine; Ornithine · CPC title
Bacteria; Culture media therefor · CPC title
- C12N9/1217Primary
Phosphotransferases with a carboxyl group as acceptor (2.7.2) · CPC title
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- What does patent US12595461B2 cover?
- The present disclosure relates to a Corynebacterium sp. mutant strain having increased L-arginine or L-citrulline productivity and a method of producing L-arginine or L-citrulline using the same. The Corynebacterium sp. mutant strain has enhanced activity of acetylglutamate kinase involved in the L-arginine biosynthesis pathway, and thus is capable of producing L-arginine or L-citrulline in…
- Who is the assignee on this patent?
- Daesang Corp
- What technology area does this patent fall under?
- Primary CPC classification C12N9/1217. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Apr 07 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).