Analysis method and device for cerebrovascular image based on cerebrovascular chunk features

Patent metadata

Field	Value
Publication number	US-12591968-B2
Application number	US-202318321934-A
Country	US
Kind code	B2
Filing date	May 23, 2023
Priority date	May 24, 2022
Publication date	Mar 31, 2026
Grant date	Mar 31, 2026

Abstract

A method of analyzing a cerebrovascular image based on cerebrovascular chunk features is disclosed, the method including receiving, by an analysis device, a cerebrovascular image of a subject; extracting, by the analysis device, a plurality of vascular unit structures from the cerebrovascular image based on geometric features of a 3D model; extracting, by the analysis device, feature values for each of the plurality of vascular unit structures; inputting, by the analysis device, the feature values of each of the plurality of vascular unit structures into a learning model trained in advance, classifying chunks to which each of the plurality of vascular unit structures belongs, and generating chunk features for the cerebrovascular image; and evaluating, by the analysis device, a condition of the subject based on the chunk features.

First claim

What is claimed is:

1 . A method of analyzing a cerebrovascular image based on cerebrovascular chunk features, the method comprising:
receiving, by an analysis device, a cerebrovascular image of a subject; extracting, by the analysis device, a plurality of vascular unit structures from the cerebrovascular image based on geometric features of a 3-Dimensional (3D) model; extracting, by the analysis device, feature values for each of the plurality of vascular unit structures; inputting, by the analysis device, the feature values of each of the plurality of vascular unit structures into a learning model trained in advance, classifying chunks to which each of the plurality of vascular unit structures belongs, and generating chunk features for the cerebrovascular image; and evaluating, by the analysis device, a condition of the subject based on the chunk features, wherein a vascular unit structure, of the vascular unit structures, is a spot, and the spot is a cell arranged at regular intervals along an artery center line extracted from the cerebrovascular image.

2 . The method of claim 1 , wherein the chunk is, as a higher structure of a vessel branch including at least one vessel branch type, the vascular unit structure segmented into different types according to at least one criterion of (i) symmetry; (ii) anterior or posterior; (iii) basal or pial; and (iv) a group including criteria of middle cerebral arteries (MCA), anterior cerebral arteries (ACA) and posterior cerebral arteries (PCA).

3 . The method of claim 1 , wherein the feature values include cerebral vessel cross-sectional area, maximum inscribed sphere radius, minimum diameter, maximum diameter, maximum-minimum radius ratio, surface circumference, distortion, curvature, and lumen roundness.

4 . The method of claim 3 , wherein the feature values further include a brightness value of the vascular unit structure.

5 . The method of claim 1 , wherein the generating of the chunk features includes:
performing, by the analysis device, primary chunk classification for each of the plurality of vascular unit structures using the learning model; and performing, by the analysis device, secondary chunk classification for the vascular unit structures belonging to same segment, in a majority voting manner based on results of the primary chunk classification of the vascular unit structures belonging to the same segment among the plurality of vascular unit structures, wherein the segment is composed of vascular unit structures belonging to a region segmented by a branch point in a vascular structure.

6 . The method of claim 1 , wherein the analysis device evaluates the condition of the subject by comparing the chunk features with reference data.

7 . The method of claim 1 , wherein the analysis device evaluates the condition of the subject by inputting the chunk features into a separate learning model learned in advance.

8 . An analysis device for analyzing a cerebrovascular image based on cerebrovascular chunk features, the device comprising:
an input unit receiving a cerebrovascular image of a subject; a storage unit storing a learning model that classifies chunks to which a vascular unit structure belongs; and a computing unit extracting a plurality of vascular unit structures based on geometric features of a 3-Dimensional (3D) model from the cerebrovascular image, inputting feature values for each of the plurality of vascular unit structures into the learning model to classify chunks to which each of the plurality of vascular unit structures belongs and generate chunk features for the cerebrovascular image, and evaluating a condition of the subject based on the chunk features, wherein the vascular unit structure is a spot, and the spot is a cell arranged at regular intervals along an artery center line extracted from the cerebrovascular image.

9 . The device of claim 8 , wherein the chunk is the vascular unit structure segmented into different types according to at least one criterion of (i) symmetry; (ii) anterior or posterior; (iii) basal or pial; and (iv) a group including criteria of middle cerebral arteries (MCA), anterior cerebral arteries (ACA) and posterior cerebral arteries (PCA), as a higher structure of a vessel branch including at least one vessel branch type.

10 . The device of claim 8 , wherein the feature values include cerebral vessel cross-sectional area, maximum inscribed sphere radius, minimum diameter, maximum diameter, maximum-minimum radius ratio, surface circumference, distortion, curvature and lumen roundness.

11 . The device of claim 10 , wherein the feature values further include a brightness value of the vascular unit structure.

12 . The device of claim 8 , wherein the computing unit performs primary chunk classification for each of the plurality of vascular unit structures using the learning model, and performs secondary chunk classification for the vascular unit structures belonging to same segment, in a majority voting manner based on results of the primary chunk classification of the vascular unit structures belonging to the same segment among the plurality of vascular unit structures; and
wherein the segment is composed of vascular unit structures belonging to a region segmented by a branch point in a vascular structure.

13 . The device of claim 8 , wherein the storage unit further stores reference data according to a phenotype; and
the computing unit compares the reference data with the chunk features to evaluate the condition of the subject.

14 . The device of claim 8 , wherein the learning model is a first learning model, and wherein the storage unit further stores a second learning model that receives chunk pattern information and classifies the condition of the subject; and
the computing unit inputs the chunk features to the second learning model and evaluates the condition of the subject based on a value output.

15 . A method of analyzing a cerebrovascular image based on cerebrovascular chunk features, the method comprising:
receiving, by an analysis device, a cerebrovascular image of a subject; extracting, by the analysis device, a plurality of vascular unit structures based on geometric features of a 3-Dimensional (3D) model from the cerebrovascular image; extracting, by the analysis device, feature values for each of the plurality of vascular unit structures; inputting, by the analysis device, the feature values of each of the plurality of vascular unit structures into a learning model trained in advance, and classifying chunks to which each of the plurality of vascular unit structures belongs; determining, by the analysis device, characteristic information on a plurality of chunks segmented in the cerebrovascular image based on the feature values of the vascular unit structure belonging to the chunk; and evaluating, by the analysis device, a condition of the subject based on the characteristic information on the plurality of chunks, wherein the vascular unit structure is a spot, and the spot is a cell arranged at regular intervals along an artery center line extracted from the cerebrovascular image.

Assignees

• Samsung Life Public Welfare Foundation

Inventors

• Seo Woo Keun
• Kim Yoon Chul
• Hong Suk Woo
• Lee Ji Eun
• Song Ha Na
• Baek In Young
• Choi Jong Un

Classifications

• A61B5/02007

  Evaluating blood vessel condition, e.g. elasticity, compliance · CPC title

• G06T2207/30101

  Blood vessel; Artery; Vein; Vascular · CPC title

• G06T2207/30016

  Brain · CPC title

• G06T2207/10088

  Magnetic resonance imaging [MRI] · CPC title

• G06T2207/20081

  Training; Learning · CPC title