Detection and treatment of CD30+ cancers
US-11366118-B2 · Jun 21, 2022 · US
US12590968B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12590968-B2 |
| Application number | US-202217747591-A |
| Country | US |
| Kind code | B2 |
| Filing date | May 18, 2022 |
| Priority date | Feb 10, 2012 |
| Publication date | Mar 31, 2026 |
| Grant date | Mar 31, 2026 |
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The application provides methods of diagnosis, prognosis, prophylaxis and treatment of CD30 + cancers.
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What is claimed is: 1 . A method of treating a CD30 positive melanoma, comprising administering an effective regimen of brentuximab vedotin to a patient having the melanoma, wherein at least 10% of the malignant or atypical cells in a sample of the melanoma have been identified as expressing CD30. 2 . The method of claim 1 , wherein at least 50% of the malignant or atypical cells in the sample have been identified as expressing CD30. 3 . The method of claim 1 , wherein CD30 expression is detected in the cell membrane and/or Golgi of the malignant or atypical cells. 4 . The method of claim 3 , wherein CD30 expression is detected after fixing the malignant or atypical cells with formalin and embedding in paraffin.
against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95 · CPC title
the antibody targeting a receptor, a cell surface antigen or a cell surface determinant · CPC title
NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30 CD40 or CD95 · CPC title
Antineoplastic agents · CPC title
involving compounds localised on the membrane of tumour or cancer cells · CPC title
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