Systems and methods for determining tissue inflammation levels of the eye from blood vessel characteristics

Patent metadata

Field	Value
Publication number	US-12588809-B2
Application number	US-202318140195-A
Country	US
Kind code	B2
Filing date	Apr 27, 2023
Priority date	Oct 10, 2019
Publication date	Mar 31, 2026
Grant date	Mar 31, 2026

Abstract

Disclosed are methods, systems, media, apparatus, devices, and other implementations, including a method that includes determining blood flow characteristics at an ocular surface of an eye of a patient, determining characteristics of blood vessels at the ocular surface of the eye based on the determined blood flow characteristics, and deriving one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the determined characteristics of the blood vessels at the ocular surface of the eye.

First claim

What is claimed is:

1 . A method comprising:
determining blood flow characteristics at an ocular surface of an eye of a patient, including
performing anterior segment (AS) optical coherence tomography angiography (OCTA) imaging for the ocular surface to detect blood flow at the ocular surface of the eye, obtaining blood flow image data for multiple layers of the ocular surface, the multiple layers comprise one or more of cornea, limbus conjunctiva, episcleral, and sclera;
determining characteristics of blood vessels at the ocular surface of the eye based on the blood flow characteristics, including
separating the blood flow image data into separate blood flow image data for one or more of the multiple layers, and
determining one or more of vessel density of the blood vessels at the ocular surface, diameters attributes of at least some of the blood vessels, and vasculature branching pattern attributes for the blood vessels measured by fractal dimension; and
deriving one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the characteristics of the blood vessels at the ocular surface of the eye.

2 . The method of claim 1 , wherein performing AS-OCTA for the ocular surface comprises:
producing images, based on the detected blood flow, representing a vasculature distribution at the ocular surface of the eye.

3 . The method of claim 1 , wherein obtaining the blood flow image data the multiple layers further comprises:
dividing the image data for at least one of the multiple layers, based on a respective reference depth for the at least one of the multiple layers, into one or more of a superficial layer image data, deep layer image data, or full thickness image data.

4 . The method of claim 1 , wherein separating the blood flow image data into separate blood flow image data sets for the respective multiple layers comprises:
separating the blood flow image data into the separate blood flow image data sets using machine learning techniques.

5 . The method of claim 1 , wherein performing AS-OCTA imaging for the ocular surface comprises:
controllably adjusting focus of a lens assembly of an OCT imaging apparatus based on one or more of: controllably actuating a focus-motor of the OCT imaging apparatus, or controllably actuating a z-motor of the OCT imaging apparatus to control a distance between the lens assembly and the eye of the patient.

6 . The method of claim 1 , wherein performing AS-OCTA imaging for the ocular surface comprises:
controlling an optical emission source of an OCT imaging apparatus to provide optical radiation controllably directed at the ocular surface, including performing one or more of: controllably adjusting the optical radiation directed to the eye of the patient so that light reflectance behavior is affected by tissue at the ocular surface of the eye, or controllably actuating activation and de-activation of the optical emission source provided to the OCT imaging apparatus.

7 . The method of claim 1 , wherein determining the characteristics of the blood vessels at the ocular surface comprises:
obtaining one or more images representative of a vasculature mapping at the ocular surface of the eye based on the determined blood flow characteristics; and processing the one or more images to determine the characteristics of the blood vessels based on image data from the processed one or more images.

8 . The method of claim 7 , wherein processing the one or more images comprises:
identifying pixels, for a particular image from the one or more images, representing blood vessels in the image; determining a ratio of the identified pixels representing the blood vessels in the image and total number of pixels in the particular image; and determining the vessel density based on the determined ratio.

9 . The method of claim 8 , wherein identifying the pixels comprises:
binarizing the particular image to convert pixels value into either a pre-determined pixel value representing blood flow, or another pre-determine pixel value representing no blood flow.

10 . The method of claim 7 , wherein processing the one or more images comprises:
identifying pixels, for a particular image from the one or more images, representing non-vessel objects in the particular image; generating a skeletonized image corresponding to the particular image comprising skeleton representations of blood vessels appearing in the particular image; identifying skeletonized pixels, for the skeletonized image, representing non-vessel objects in the skeletonized image; and deriving a vessel diameter index based on the identified pixels representing the non-vessel objects in the particular image and the identified skeletonized pixels representing the non-vessel objects in the skeletonized image.

11 . The method of claim 7 , wherein processing the one or more images comprises:
performing fractal dimension analysis of vessels appearing in the one or more images to determine vasculature branching pattern complexity of the blood vessels at the ocular surface of the eye.

12 . The method of claim 1 , further comprising:
determining one or more medical conditions of the patient based on the derived one or more ocular redness grading scales.

13 . A system to determine inflammation level of an eye of a patient, the system comprising:
an imaging apparatus to determine blood flow characteristics at an ocular surface of the eye of the patient, comprising:
an anterior segment (AS) optical coherence tomography angiography (OCTA) imaging apparatus; and
a controller configured to:
perform AS-OCTA imaging for the ocular surface to detect blood flow at the ocular surface of the eye;
determine characteristics of blood vessels at the ocular surface of the eye based on the determined blood flow characteristics;
determine one or more of vessel density of the blood vessels at the ocular surface, diameter attributes of at least some of the blood vessels, and vasculature branching pattern attributes for the blood vessels measured by fractal dimension; and
derive one or more ocular redness grading scales indicative of inflammation levels of the eye of the patient based on the determined characteristics of the blood vessels at the ocular surface of the eye.

14 . The system of claim 13 , wherein the AS-OCTA imaging apparatus is configured to produce images based on the detected blood flow representing a vasculature distribution at the ocular surface of the eye.

15 . The system of claim 13 , wherein the controller configured to perform AS-OCTA imaging for the ocular surface to detect blood flow at the ocular surface is configured to:
obtain blood flow image data for multiple layers of the ocular surface, the multiple layers comprise one or more of: cornea, limbus, conjunctiva, episcleral, or sclera; and separate the blood flow image data into separate blood flow image data sets for: one or more of respective multiple layers, or into one or more of a superficial layer, a deep layer, or full thickness layer.

16 . The system of claim 15 , wherein the controller further comprises a machine learning engine configured to separate the blood flow image data into the separate blood flow image data sets based on machine learning techniques.

17 . The system of claim 13 , wherein the controller configured to perform AS-OCTA imaging for the ocular surface is configured to:
controllably adjust focus of a lens assembly coupled to an OCT imaging apparatus based on one or more of: controllably actuating a focus-motor

Assignees

• Tufts Medical Ct Inc

Inventors

• Hamrah Pedram
• Binotti William Warr
• Nose Ricardo Menon

Classifications

• A61F9/0017

  implantable in, or in contact with, the eye, e.g. ocular inserts · CPC title

• A61B3/102 Primary

  for optical coherence tomography [OCT] · CPC title