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US-2019153391-A1 · May 23, 2019 · US
Coating agent for inducing differentiation of pluripotent stem cells into brain microvascular endothelium-like cells and use thereof
US12584906B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12584906-B2 |
| Application number | US-202117798206-A |
| Country | US |
| Kind code | B2 |
| Filing date | Feb 9, 2021 |
| Priority date | Feb 10, 2020 |
| Publication date | Mar 24, 2026 |
| Grant date | Mar 24, 2026 |
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- Title
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Abstract
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Provided is a technology allowing for stable supply of brain microvascular endothelium-like cells. This coating agent for inducing differentiation of pluripotent stem cells into brain microvascular endothelium-like cells contains at least one component of a Laminin-221 fragment or an N-terminal Vitronectin.
First claim
Opening claim text (preview).
The invention claimed is: 1 . A method of producing brain microvascular endothelium cells by inducing differentiation of pluripotent stem cells, comprising a step of culturing the pluripotent stem cells on a culture surface that is coated with at least a Laminin-221 fragment. 2 . The method of producing brain microvascular endothelium cells according to claim 1 , wherein the pluripotent stem cells are induced pluripotent stem cells. 3 . The method of producing brain microvascular endothelium cells according to claim 2 , wherein the induced pluripotent stem cells are human induced pluripotent stem cells. 4 . The method of producing brain microvascular endothelium cells according to claim 1 , wherein the pluripotent stem cells are cultured on said culture surface that is coated with a Laminin-221 fragment at the initiation of differentiation induction.
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Classifications
Collagen; Gelatin · CPC title
Fibronectin; Laminin · CPC title
from artificially induced pluripotent stem cells · CPC title
Stem cells; Progenitor cells; Precursor cells · CPC title
Endothelial cells · CPC title
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Frequently asked questions
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- What does patent US12584906B2 cover?
- Provided is a technology allowing for stable supply of brain microvascular endothelium-like cells. This coating agent for inducing differentiation of pluripotent stem cells into brain microvascular endothelium-like cells contains at least one component of a Laminin-221 fragment or an N-terminal Vitronectin.
- Who is the assignee on this patent?
- Univ Nagoya City Public Univ Corp
- What technology area does this patent fall under?
- Primary CPC classification G01N33/5082. Mapped technology areas include Physics.
- When was this patent published?
- Publication date Tue Mar 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 6 related publications on this page (citations in our corpus or others sharing the same primary CPC).