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Separation of nucleic acid component compounds on zwitterionic stationary phases
US12584159B2 · US · B2
| Field | Value |
|---|---|
| Publication number | US-12584159-B2 |
| Application number | US-202217831641-A |
| Country | US |
| Kind code | B2 |
| Filing date | Jun 3, 2022 |
| Priority date | Jun 4, 2021 |
| Publication date | Mar 24, 2026 |
| Grant date | Mar 24, 2026 |
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Abstract
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The present disclosure pertains to methods of separating nucleic acid component compounds from one another. In some embodiments, the methods comprise: (a) loading a sample fluid comprising a plurality of nucleic acid component compounds onto a chromatographic column comprising a zwitterionic stationary phase contained inside the column; (b) flowing a mobile phase through the chromatographic column over a time period thereby forming an eluent in which at least some of the plurality of the nucleic acid component compounds are separated from each other, the mobile phase comprising a polar aprotic solvent, a protic solvent, and a volatile buffer salt, wherein flowing the mobile phase comprises varying a ratio of the protic solvent to the polar aprotic solvent over at least a portion of the time period and varying an ionic strength of the volatile buffer salt over at least a portion of the time period.
First claim
Opening claim text (preview).
What is claimed is: 1 . A method comprising: (a) loading a sample fluid comprising a plurality of nucleic acid component compounds onto a chromatographic column comprising a zwitterionic stationary phase contained inside the column, wherein the zwitterionic stationary phase is a particulate stationary phase and comprises (i) a bulk material comprising an ethylene bridged hybrid (BEH) material, and (ii) zwitterionic surface groups covalently linked to the bulk material or a zwitte…
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Physics · mapped topic
Physics · mapped topic
Chemistry & Metallurgy · mapped topic
Chemistry & Metallurgy · mapped topic
Operations & Transport · mapped topic
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Frequently asked questions
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- What does patent US12584159B2 cover?
- The present disclosure pertains to methods of separating nucleic acid component compounds from one another. In some embodiments, the methods comprise: (a) loading a sample fluid comprising a plurality of nucleic acid component compounds onto a chromatographic column comprising a zwitterionic stationary phase contained inside the column; (b) flowing a mobile phase through the chromatographic col…
- Who is the assignee on this patent?
- Waters Technologies Corp
- What technology area does this patent fall under?
- Primary CPC classification C12Q1/68. Mapped technology areas include Chemistry & Metallurgy.
- When was this patent published?
- Publication date Tue Mar 24 2026 00:00:00 GMT+0000 (Coordinated Universal Time) (B2). Legal status and post-grant events are not shown on this page.
- What related patents are in patentsdb?
- We list 8 related publications on this page (citations in our corpus or others sharing the same primary CPC).