Vesicle-coated fibers and methods of making and using

Patent metadata

Field	Value
Publication number	US-12577726-B2
Application number	US-201917293905-A
Country	US
Kind code	B2
Filing date	Nov 14, 2019
Priority date	Nov 15, 2018
Publication date	Mar 17, 2026
Grant date	Mar 17, 2026

Abstract

Methods and compositions for rapid and efficient assembly of fibers coated with lamellar vesicles are provided. Cosmetic and therapeutic uses of vesicle-coated fibers are also provided.

First claim

What is claimed is:

1 . A method for making a vesicle-coated substrate, the method comprising:
(a i) dispersing an amphiphilic molecule in a solvent; (a ii) coating a paper substrate with a polymer selected from one of carboxymethylcellulose, dextran and polypeptides; (b) contacting the dispersed amphiphilic molecule of (a i) with the fibrous-substrate; (c) removing the solvent; and (d) incubating the amphiphile-coated substrate in a growth buffer solution having a temperature that is less than the transition temperature of the amphiphilic molecule, wherein the ionic strength of the growth buffer is less than 10 mM monovalent salt and increased during the incubation to higher than 10 mM monovalent salt, and wherein vesiculation is induced by increasing the temperature of the growth buffer to a temperature greater than the transition temperature of the amphiphile, wherein vesicles encapsulates hydrophilic molecules within their lumen, and wherein the encapsulated hydrophilic molecules are protected until they are released from the vesicles.

2 . The method of claim 1 , wherein the amphiphilic molecule is selected from the group consisting of a phospholipid, a sphingolipid, a fatty acid, a quaternary ammonium surfactant, a ceramide, a fatty alcohol, an amphiphilic polymer, a diblock polymer or a triblock polymer.

3 . The method of claim 1 , further comprising, prior to step (d), introducing a compound into the growth buffer solution.

4 . The method of claim 1 , further comprising, in step (a), dispersing a second molecule in the solvent.

5 . The method of claim 4 , wherein the second molecule is hydrophilic and the solvent is water.

Assignees

• Univ California

Inventors

• Subramaniam Anand Bala
• Pazzi Joseph
• Girish Vaishnavi

Classifications

• D21H19/82

  superposed {(D21H19/84 takes precedence)} · CPC title

• D06M15/647

  containing polyether sequences · CPC title

• D06M13/203

  Unsaturated carboxylic acids; Anhydrides, halides or salts thereof · CPC title

• A61K9/1277

  Preparation processes; Proliposomes · CPC title

• A61K9/1273

  Polymersomes; Liposomes with polymerisable or polymerised bilayer-forming substances · CPC title