Aryl receptor modulators and methods of making and using the same

Patent metadata

Field	Value
Publication number	US-12577256-B2
Application number	US-202418656965-A
Country	US
Kind code	B2
Filing date	May 7, 2024
Priority date	Jun 27, 2014
Publication date	Mar 17, 2026
Grant date	Mar 17, 2026

Abstract

The present invention is generally directed towards compounds capable of binding the aryl hydrocarbon receptor and modulating its activity, methods of treating inflammatory conditions such as Crohn's disease using such compounds, and pharmaceutical compositions comprising such compounds. Also provided are methods of increasing levels of IL-22 in a subject and/or decreasing levels of IFN-7 in a subject.

First claim

What is claimed is:

1 . A compound represented by:

or a pharmaceutically acceptable salt thereof.

2 . A pharmaceutical composition comprising a compound according to claim 1 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

3 . A method of treating or reducing fibrostenosis or intestinal fibrosis in a subject, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound according to claim 1 , or a pharmaceutically acceptable salt thereof.

4 . A compound represented by:

or a pharmaceutically acceptable salt thereof.

5 . A pharmaceutical composition comprising a compound according to claim 4 , or a pharmaceutically acceptable salt thereof; and a pharmaceutically acceptable carrier.

6 . A method of treating or reducing fibrostenosis or intestinal fibrosis in a subject, the method comprising administering to a subject in need thereof a therapeutically effective amount of a compound according to claim 4 , or a pharmaceutically acceptable salt thereof.

Assignees

• Nogra Pharma Ltd

Inventors

• Viti Francesca
• Bellinvia Salvatore
• Demartis Salvatore

Classifications

• C07D333/36

  Nitrogen atoms · CPC title

• C07D277/82

  Nitrogen atoms · CPC title

• C07D277/64

  with only hydrocarbon or substituted hydrocarbon radicals attached in position 2 · CPC title

• C07D235/30

  Nitrogen atoms not forming part of a nitro radical · CPC title

• C07D213/75

  Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates · CPC title